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Herynek V, Turnovcová K, Gálisová A, et al. Manganese-Zinc Ferrites: Safe and Efficient Nanolabels for Cell Imaging and Tracking In Vivo. ChemistryOpen. 2019;8(2):155-165doi: 10.1002/open.201800261.
Herynek, V., Turnovcová, K., Gálisová, A., Kaman, O., Mareková, D., Koktan, J., Vosmanská, M., Kosinová, L., & Jendelová, P. (2019). Manganese-Zinc Ferrites: Safe and Efficient Nanolabels for Cell Imaging and Tracking In Vivo. ChemistryOpen, 8(2), 155-165. https://doi.org/10.1002/open.201800261
Herynek, Vít, et al. "Manganese-Zinc Ferrites: Safe and Efficient Nanolabels for Cell Imaging and Tracking In Vivo." ChemistryOpen vol. 8,2 (2019): 155-165. doi: https://doi.org/10.1002/open.201800261
Herynek V, Turnovcová K, Gálisová A, Kaman O, Mareková D, Koktan J, Vosmanská M, Kosinová L, Jendelová P. Manganese-Zinc Ferrites: Safe and Efficient Nanolabels for Cell Imaging and Tracking In Vivo. ChemistryOpen. 2019 Jan 23;8(2):155-165. doi: 10.1002/open.201800261. eCollection 2019 Feb. PMID: 30740290; PMCID: PMC6356160.
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ChemistryOpen. 2019 Jan 23;8(2):155-165. doi: 10.1002/open.201800261. eCollection 2019 Feb.

Manganese-Zinc Ferrites: Safe and Efficient Nanolabels for Cell Imaging and Tracking In Vivo.

ChemistryOpen

Vít Herynek, Karolína Turnovcová, Andrea Gálisová, Ondřej Kaman, Dana Mareková, Jakub Koktan, Magda Vosmanská, Lucie Kosinová, Pavla Jendelová

Affiliations

  1. Radiodiagnostic and Interventional Radiology Department Institute for Clinical and Experimental Medicine Víde?ská 1958/9 140 21 Prague Czech Republic.
  2. Center for Advanced Preclinical Imaging First Faculty of Medicine Charles University Salmovská 3 Prague Czech Republic.
  3. Department of Tissue Culture and Stem Cells Institute of Experimental Medicine, Czech Academy of Sciences Víde?ská 1083 Prague Czech Republic.
  4. Institute of Physics, Czech Academy of Sciences Cukrovarnická 10 Prague Czech Republic.
  5. Faculty of Chemical Engineering University of Chemistry and Technology Technická 5 Prague Czech Republic.
  6. Experimental Medicine Centre Institute for Clinical and Experimental Medicine Víde?ská 1958/9 Prague Czech Republic.

PMID: 30740290 PMCID: PMC6356160 DOI: 10.1002/open.201800261

Abstract

Manganese-zinc ferrite nanoparticles were synthesized by using a hydrothermal treatment, coated with silica, and then tested as efficient cellular labels for cell tracking, using magnetic resonance imaging (MRI) in vivo. A toxicity study was performed on rat mesenchymal stem cells and C6 glioblastoma cells. Adverse effects on viability and cell proliferation were observed at the highest concentration (0.55 mM) only; cell viability was not compromised at lower concentrations. Nanoparticle internalization was confirmed by transmission electron microscopy. The particles were found in membranous vesicles inside the cytoplasm. Although the metal content (0.42 pg Fe/cell) was lower compared to commercially available iron oxide nanoparticles, labeled cells reached a comparable relaxation rate

Keywords: cell labeling; cell transplantation; doping; magnetic resonance imaging; nanoparticles

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