Display options
Cite
Nestal de Moraes G, Carneiro LDT, Maia RC, et al. FOXK2 Transcription Factor and Its Emerging Roles in Cancer. Cancers (Basel). 2019;11(3)doi: 10.3390/cancers11030393.
Nestal de Moraes, G., Carneiro, L. D. T., Maia, R. C., Lam, E. W., & Sharrocks, A. D. (2019). FOXK2 Transcription Factor and Its Emerging Roles in Cancer. Cancers, 11(3), . https://doi.org/10.3390/cancers11030393
Nestal de Moraes, Gabriela, et al. "FOXK2 Transcription Factor and Its Emerging Roles in Cancer." Cancers vol. 11,3 (2019). doi: https://doi.org/10.3390/cancers11030393
Nestal de Moraes G, Carneiro LDT, Maia RC, Lam EW, Sharrocks AD. FOXK2 Transcription Factor and Its Emerging Roles in Cancer. Cancers (Basel). 2019 Mar 20;11(3). doi: 10.3390/cancers11030393. PMID: 30897782; PMCID: PMC6468357.
Copy Download .nbib Format: NLM
Share it on

Cancers (Basel). 2019 Mar 20;11(3). doi: 10.3390/cancers11030393.

FOXK2 Transcription Factor and Its Emerging Roles in Cancer.

Cancers

Gabriela Nestal de Moraes, Luciana da Torre Carneiro, Raquel Ciuvalschi Maia, Eric Wing-Fai Lam, Andrew David Sharrocks

Affiliations

  1. Laboratório de Hemato-Oncologia Celular e Molecular, Programa de Hemato-Oncologia Molecular, Instituto Nacional do Câncer (INCA), Praça da Cruz Vermelha, 23, 6° andar, Rio de Janeiro (RJ) 20230 130, Brazil. [email protected].
  2. Laboratório de Hemato-Oncologia Celular e Molecular, Programa de Hemato-Oncologia Molecular, Instituto Nacional do Câncer (INCA), Praça da Cruz Vermelha, 23, 6° andar, Rio de Janeiro (RJ) 20230 130, Brazil. [email protected].
  3. Laboratório de Hemato-Oncologia Celular e Molecular, Programa de Hemato-Oncologia Molecular, Instituto Nacional do Câncer (INCA), Praça da Cruz Vermelha, 23, 6° andar, Rio de Janeiro (RJ) 20230 130, Brazil. [email protected].
  4. Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK. [email protected].
  5. Faculty of Biology, Medicine and Health, University of Manchester, Oxford Rd, Manchester M13 9PL, UK. [email protected].

PMID: 30897782 PMCID: PMC6468357 DOI: 10.3390/cancers11030393

Abstract

Forkhead box (FOX) transcription factors compose a large family of regulators of key biological processes within a cell. FOXK2 is a member of FOX family, whose biological functions remain relatively unexplored, despite its description in the early nineties. More recently, growing evidence has been pointing towards a role of FOXK2 in cancer, which is likely to be context-dependent and tumour-specific. Here, we provide an overview of important aspects concerning the mechanisms of regulation of FOXK2 expression and function, as well as its complex interactions at the chromatin level, which orchestrate how it differentially regulates the expression of gene targets in pathophysiology. Particularly, we explore the emerging functions of FOXK2 as a regulator of a broad range of cancer features, such as cell proliferation and survival, DNA damage, metabolism, migration, invasion and metastasis. Finally, we discuss the prognostic value of assessing FOXK2 expression in cancer patients and how it can be potentially targeted for future anticancer interventions.

Keywords: FOXK2 transcription factor; cancer; forkhead box; transcriptional activity

References

  1. Biochem J. 2000 Jan 15;345 Pt 2:335-43 - PubMed
  2. Genes Dev. 2000 Jan 15;14(2):142-6 - PubMed
  3. Proc Natl Acad Sci U S A. 2000 May 9;97(10):5416-21 - PubMed
  4. Nature. 2000 Jul 6;406(6791):90-4 - PubMed
  5. Genomics. 1992 Jul;13(3):665-71 - PubMed
  6. Int J Mol Med. 2004 Jul;14(1):127-32 - PubMed
  7. Mol Cell Biol. 2004 Nov;24(22):10036-46 - PubMed
  8. J Cell Sci. 2004 Dec 1;117(Pt 25):5965-73 - PubMed
  9. Nature. 2006 Nov 23;444(7118):494-8 - PubMed
  10. Nat Rev Cancer. 2007 Nov;7(11):847-59 - PubMed
  11. Cell Metab. 2007 Dec;6(6):472-83 - PubMed
  12. Proc Natl Acad Sci U S A. 1991 Sep 1;88(17):7739-43 - PubMed
  13. J Virol. 2010 Mar;84(6):2719-31 - PubMed
  14. J Biochem. 2010 May;147(5):705-9 - PubMed
  15. J Biol Chem. 2010 Nov 12;285(46):35728-39 - PubMed
  16. Mol Cell Biol. 2012 Jan;32(2):385-98 - PubMed
  17. Mol Cell Biochem. 2012 Jul;366(1-2):251-8 - PubMed
  18. PLoS Genet. 2012;8(4):e1002630 - PubMed
  19. Cell. 2013 Feb 28;152(5):1146-59 - PubMed
  20. Nat Rev Cancer. 2013 Mar;13(3):153-9 - PubMed
  21. Nat Rev Cancer. 2013 Jul;13(7):482-95 - PubMed
  22. Nat Rev Mol Cell Biol. 2013 Sep;14(9):563-80 - PubMed
  23. Am J Med Genet A. 2013 Dec;161A(12):3144-9 - PubMed
  24. Genome Biol. 2013;14(10):R119 - PubMed
  25. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):285-90 - PubMed
  26. Proteomics. 2014 Oct;14(19):2179-89 - PubMed
  27. Nucleic Acids Res. 2014 Jun;42(10):6232-42 - PubMed
  28. J Cell Physiol. 2015 May;230(5):1013-23 - PubMed
  29. Nat Cell Biol. 2014 Dec;16(12):1202-14 - PubMed
  30. J Biol Chem. 2015 Jan 16;290(3):1580-91 - PubMed
  31. Sci Rep. 2015 Mar 05;5:8796 - PubMed
  32. Dev Cell. 2015 Mar 23;32(6):707-18 - PubMed
  33. Epigenomics. 2015;7(6):1051-73 - PubMed
  34. Oncogenesis. 2015 Sep 07;4:e167 - PubMed
  35. Nucleic Acids Res. 2016 Feb 29;44(4):1566-78 - PubMed
  36. Jpn J Clin Oncol. 2016 Mar;46(3):209-21 - PubMed
  37. PLoS One. 2016 Aug 03;11(8):e0160594 - PubMed
  38. Cancer Cell. 2016 Nov 14;30(5):708-722 - PubMed
  39. Oncogenesis. 2016 Nov 28;5(11):e271 - PubMed
  40. Prog Biophys Mol Biol. 2017 Aug;127:105-110 - PubMed
  41. Biochem Biophys Res Commun. 2017 Jan 29;483(1):475-481 - PubMed
  42. Biochem Soc Trans. 2017 Feb 8;45(1):193-205 - PubMed
  43. Oncol Rep. 2017 Apr;37(4):2335-2347 - PubMed
  44. Int J Biochem Cell Biol. 2017 Jul;88:155-161 - PubMed
  45. Int J Cancer. 2018 Jun 15;142(12):2543-2557 - PubMed
  46. Onco Targets Ther. 2018 Feb 27;11:1067-1075 - PubMed
  47. Oncogenesis. 2018 Mar 13;7(3):29 - PubMed
  48. Cancer. 2018 Aug;124(16):3307-3318 - PubMed
  49. Mol Nutr Food Res. 2018 Apr 24;:e1700933 - PubMed
  50. Oncol Lett. 2018 Jun;15(6):8669-8680 - PubMed
  51. Mol Cell. 2018 Jun 7;70(5):949-960.e4 - PubMed
  52. J Mol Biol. 2018 Oct 26;430(22):4456-4468 - PubMed
  53. Clin Epigenetics. 2018 Aug 23;10(1):110 - PubMed
  54. Mol Med Rep. 2018 Nov;18(5):4356-4364 - PubMed
  55. Nature. 2019 Feb;566(7743):279-283 - PubMed
  56. J Biol Chem. 1997 Mar 21;272(12):7736-45 - PubMed

Publication Types

Grant support