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Rafique Z, Chouihed T, Mebazaa A, et al. Current treatment and unmet needs of hyperkalaemia in the emergency department. Eur Heart J Suppl. 2019;21:A12-A19doi: 10.1093/eurheartj/suy029.
Rafique, Z., Chouihed, T., Mebazaa, A., & Frank Peacock, W. (2019). Current treatment and unmet needs of hyperkalaemia in the emergency department. European heart journal supplements : journal of the European Society of Cardiology, 21A12-A19. https://doi.org/10.1093/eurheartj/suy029
Rafique, Zubaid, et al. "Current treatment and unmet needs of hyperkalaemia in the emergency department." European heart journal supplements : journal of the European Society of Cardiology vol. 21 (2019): A12-A19. doi: https://doi.org/10.1093/eurheartj/suy029
Rafique Z, Chouihed T, Mebazaa A, Frank Peacock W. Current treatment and unmet needs of hyperkalaemia in the emergency department. Eur Heart J Suppl. 2019 Feb;21:A12-A19. doi: 10.1093/eurheartj/suy029. Epub 2019 Feb 26. PMID: 30837800; PMCID: PMC6392420.
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Eur Heart J Suppl. 2019 Feb;21:A12-A19. doi: 10.1093/eurheartj/suy029. Epub 2019 Feb 26.

Current treatment and unmet needs of hyperkalaemia in the emergency department.

European heart journal supplements : journal of the European Society of Cardiology

Zubaid Rafique, Tahar Chouihed, Alexandre Mebazaa, W Frank Peacock

Affiliations

  1. Baylor College of Medicine, Ben Taub General Hospital, Houston, TX, USA.
  2. Emergency Department, University Hospital of Nancy, France; Clinical Investigation Center-Unit 1433; INSERM U1116, University of Lorraine, Nancy, France.
  3. Department of Anesthesiology and Critical Care, APHP - Saint Louis Lariboisière University Hospitals, University Paris Diderot and INSERM UMR-S 942, Paris, France.

PMID: 30837800 PMCID: PMC6392420 DOI: 10.1093/eurheartj/suy029

Abstract

Hyperkalaemia is a common electrolyte abnormality and can cause life-threatening cardiac arrhythmia. Even though it is common in patients with diabetes, heart failure, and kidney disease, there is poor consensus over its definition and wide variability in its treatment. Medications used to treat hyperkalaemia in the emergent setting do not have robust efficacy and safety data to guide treatment leading to mismanagement due to poor choice of some agents or inappropriate dosing of others. Moreover, the medications used in the emergent setting are at best temporizing measures, with dialysis being the definitive treatment. New and old k binder therapies provide means to excrete potassium, but their roles are unclear in the emergent setting. Electrocardiograms are the corner stones of hyperkalaemia management; however, recent studies show that they might manifest abnormalities infrequently, even in severe hyperkalaemia, thus questioning their role. With an aging population and a rise in rates of heart and kidney failure, hyperkalaemia is on the rise, and there is a need, now more than ever, to understand the efficacy and safety of the current medications and to develop newer ones.

Keywords: Algorithm; Electrocardiogram; Hyperkalaemia; Potassium; Treatment

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