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Sheats MK. A Comparative Review of Equine SIRS, Sepsis, and Neutrophils. Front Vet Sci. 2019;6:69doi: 10.3389/fvets.2019.00069.
Sheats, M. K. (2019). A Comparative Review of Equine SIRS, Sepsis, and Neutrophils. Frontiers in veterinary science, 669. https://doi.org/10.3389/fvets.2019.00069
Sheats, M Katie. "A Comparative Review of Equine SIRS, Sepsis, and Neutrophils." Frontiers in veterinary science vol. 6 (2019): 69. doi: https://doi.org/10.3389/fvets.2019.00069
Sheats MK. A Comparative Review of Equine SIRS, Sepsis, and Neutrophils. Front Vet Sci. 2019 Mar 12;6:69. doi: 10.3389/fvets.2019.00069. eCollection 2019. PMID: 30931316; PMCID: PMC6424004.
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Front Vet Sci. 2019 Mar 12;6:69. doi: 10.3389/fvets.2019.00069. eCollection 2019.

A Comparative Review of Equine SIRS, Sepsis, and Neutrophils.

Frontiers in veterinary science

M Katie Sheats

Affiliations

  1. Department of Clinical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, NC, United States.

PMID: 30931316 PMCID: PMC6424004 DOI: 10.3389/fvets.2019.00069

Abstract

The most recent definition of sepsis in human medicine can be summarized as organ dysfunction caused by a dysregulated host response to infection. In equine medicine, although no consensus definition is available, sepsis is commonly described as a dysregulated host systemic inflammatory response to infection. Defense against host infection is the primary role of innate immune cells known as neutrophils. Neutrophils also contribute to host injury during sepsis, making them important potential targets for sepsis prevention, diagnosis, and treatment. This review will present both historical and updated perspectives on the systemic inflammatory response (SIRS) and sepsis; it will also discuss the impact of sepsis on neutrophils, and the impact of neutrophils during sepsis. Future identification of clinically relevant sepsis diagnosis and therapy depends on a more thorough understanding of disease pathogenesis across species. To gain this understanding, there is a critical need for research that utilizes a clearly defined, and consistently applied, classification system for patients diagnosed with, and at risk of developing, sepsis.

Keywords: endotoxemia; neutrophil; organ dysfunction; sepsis; systemic inflammatory response

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