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Tuominen H, Haarala A, Tikkakoski A, et al. FDG-PET in possible cardiac sarcoidosis: Right ventricular uptake and high total cardiac metabolic activity predict cardiovascular events. J Nucl Cardiol. 2019;28(1):199-205doi: 10.1007/s12350-019-01659-2.
Tuominen, H., Haarala, A., Tikkakoski, A., Kähönen, M., Nikus, K., & Sipilä, K. (2021). FDG-PET in possible cardiac sarcoidosis: Right ventricular uptake and high total cardiac metabolic activity predict cardiovascular events. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 28(1), 199-205. https://doi.org/10.1007/s12350-019-01659-2
Tuominen, Heikki, et al. "FDG-PET in possible cardiac sarcoidosis: Right ventricular uptake and high total cardiac metabolic activity predict cardiovascular events." Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology vol. 28,1 (2021): 199-205. doi: https://doi.org/10.1007/s12350-019-01659-2
Tuominen H, Haarala A, Tikkakoski A, Kähönen M, Nikus K, Sipilä K. FDG-PET in possible cardiac sarcoidosis: Right ventricular uptake and high total cardiac metabolic activity predict cardiovascular events. J Nucl Cardiol. 2021 Feb;28(1):199-205. doi: 10.1007/s12350-019-01659-2. Epub 2019 Feb 27. PMID: 30815833; PMCID: PMC7920884.
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J Nucl Cardiol. 2021 Feb;28(1):199-205. doi: 10.1007/s12350-019-01659-2. Epub 2019 Feb 27.

FDG-PET in possible cardiac sarcoidosis: Right ventricular uptake and high total cardiac metabolic activity predict cardiovascular events.

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

Heikki Tuominen, Atte Haarala, Antti Tikkakoski, Mika Kähönen, Kjell Nikus, Kalle Sipilä

Affiliations

  1. Department of Clinical Physiology and Nuclear Medicine, Tampere University Hospital, 33520, Tampere, Finland. [email protected].
  2. Department of Clinical Physiology and Nuclear Medicine, Tampere University Hospital, 33520, Tampere, Finland.
  3. Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
  4. Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland.

PMID: 30815833 PMCID: PMC7920884 DOI: 10.1007/s12350-019-01659-2

Abstract

BACKGROUND: Cardiac involvement accounts for the majority of morbidity and mortality in sarcoidosis. Pathological myocardial fluorodeoxyglucose (FDG)-uptake in positron emission tomography (PET) has been associated with cardiovascular events and quantitative metabolic parameters have been shown to add prognostic value. Our aim was to study whether the pattern of pathological cardiac FDG-uptake and quantitative parameters are able to predict cardiovascular events in patients with suspected cardiac sarcoidosis (CS).

METHODS: 137 FDG-PET examinations performed in Tampere University Hospital were retrospectively analyzed visually and quantitatively. Location of pathological uptake was noted and pathological metabolic volume, average standardized uptake value (SUV), and total cardiac metabolic activity (tCMA) were calculated. Patients were followed for ventricular tachycardia, decrease in left ventricular ejection fraction, and death.

RESULTS: Eleven patients had one or more cardiovascular events during the follow-up. Five patients out of 12 with uptake in both ventricles had an event during follow-up. Eight patients had high tCMA (> 900 MBq) and three of them had a cardiovascular event. Right ventricular uptake and tCMA were significantly associated with cardiovascular events during follow-up (P-value .001 and .018, respectively).

CONCLUSIONS: High tCMA and right ventricular uptake were significant risk markers for cardiac events among patient with suspected CS.

Keywords: PET; Sarcoid heart dusease; inflammation; metabolism imaging agents

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