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De Berardis D, Olivieri L, Rapini G, et al. Alexithymia, Suicide Ideation and Homocysteine Levels in Drug Naïve Patients with Major Depression: A Study in the "Real World" Clinical Practice. Clin Psychopharmacol Neurosci. 2019;17(2):318-322doi: 10.9758/cpn.2019.17.2.318.
De Berardis, D., Olivieri, L., Rapini, G., Di Natale, S., Serroni, N., Fornaro, M., Orsolini, L., Valchera, A., Carano, A., Vellante, F., Varasano, P. A., Lucidi Pressanti, G., Serafini, G., Pompili, M., Martinotti, G., & Di Giannantonio, M. (2019). Alexithymia, Suicide Ideation and Homocysteine Levels in Drug Naïve Patients with Major Depression: A Study in the "Real World" Clinical Practice. Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology, 17(2), 318-322. https://doi.org/10.9758/cpn.2019.17.2.318
De Berardis, Domenico, et al. "Alexithymia, Suicide Ideation and Homocysteine Levels in Drug Naïve Patients with Major Depression: A Study in the "Real World" Clinical Practice." Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology vol. 17,2 (2019): 318-322. doi: https://doi.org/10.9758/cpn.2019.17.2.318
De Berardis D, Olivieri L, Rapini G, Di Natale S, Serroni N, Fornaro M, Orsolini L, Valchera A, Carano A, Vellante F, Varasano PA, Lucidi Pressanti G, Serafini G, Pompili M, Martinotti G, Di Giannantonio M. Alexithymia, Suicide Ideation and Homocysteine Levels in Drug Naïve Patients with Major Depression: A Study in the "Real World" Clinical Practice. Clin Psychopharmacol Neurosci. 2019 May 31;17(2):318-322. doi: 10.9758/cpn.2019.17.2.318. PMID: 30905133; PMCID: PMC6478096.
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Clin Psychopharmacol Neurosci. 2019 May 31;17(2):318-322. doi: 10.9758/cpn.2019.17.2.318.

Alexithymia, Suicide Ideation and Homocysteine Levels in Drug Naïve Patients with Major Depression: A Study in the "Real World" Clinical Practice.

Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology

Domenico De Berardis, Luigi Olivieri, Gabriella Rapini, Serena Di Natale, Nicola Serroni, Michele Fornaro, Laura Orsolini, Alessandro Valchera, Alessandro Carano, Federica Vellante, Paola Annunziata Varasano, Gabriella Lucidi Pressanti, Gianluca Serafini, Maurizio Pompili, Giovanni Martinotti, Massimo Di Giannantonio

Affiliations

  1. National Health Service, Department of Mental Health, Psychiatric Service of Diagnosis and Treatment, Hospital "G. Mazzini".
  2. Department of Neurosciences and Imaging, University "G. D'Annunzio".
  3. Department of Psychiatry, Federico II University.
  4. Polyedra, Teramo.
  5. School of Life and Medical Sciences, University of Hertfordshire, Hatfield.
  6. Villa S. Giuseppe Hospital, Hermanas Hospitalarias.
  7. Department of Mental Health, Psychiatric Service of Diagnosis and Treatment, Hospital "Madonna Del Soccorso", National Health Service.
  8. Department of Immunohematology and Transfusional Medicine, "G. Mazzini" Hospital.
  9. Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa.
  10. Department of Neurosciences, Mental Health and Sensory Organs, Suicide Prevention Center, Sant'Andrea Hospital, Sapienza University of Rome.

PMID: 30905133 PMCID: PMC6478096 DOI: 10.9758/cpn.2019.17.2.318

Abstract

OBJECTIVE: : This study was performed to elucidate relationships between alexithymia, suicide ideation and homocysteine levels in drug-naïve outpatients with major depressive disorder (MDD).

METHODS: : Sixty seven outpatients with MDD with melancholic features were evaluated by the means of the Hamilton Depression Rating Scale, the Toronto Alexithymia Scale (TAS-20), the Scale of Suicide Ideation, and homocysteine levels.

RESULTS: : Alexithymic subjects showed higher scores on all scales and higher homocysteine levels. Regression analysis shown higher homocysteine levels and TAS-20' "Difficulty in Describing Feelings" dimension, in turn being associated with higher suicide ideation.

CONCLUSION: : In conclusion, alexithymic MDD outpatients may characterize for homocysteine dysregulation that may be linked to suicide ideation, regardless depression' severity. However, study limitations are discussed and must be considered.

Keywords: Affective symptoms; Alexithymia; Depression; Homocysteine; Suicidal ideation

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