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Rafael D, Andrade F, Martinez-Trucharte F, et al. Sterilization Procedure for Temperature-Sensitive Hydrogels Loaded with Silver Nanoparticles for Clinical Applications. Nanomaterials (Basel). 2019;9(3)doi: 10.3390/nano9030380.
Rafael, D., Andrade, F., Martinez-Trucharte, F., Basas, J., Seras-Franzoso, J., Palau, M., Gomis, X., Pérez-Burgos, M., Blanco, A., López-Fernández, A., Vélez, R., Abasolo, I., Aguirre, M., Gavaldà, J., & Schwartz, S. (2019). Sterilization Procedure for Temperature-Sensitive Hydrogels Loaded with Silver Nanoparticles for Clinical Applications. Nanomaterials (Basel, Switzerland), 9(3), . https://doi.org/10.3390/nano9030380
Rafael, Diana, et al. "Sterilization Procedure for Temperature-Sensitive Hydrogels Loaded with Silver Nanoparticles for Clinical Applications." Nanomaterials (Basel, Switzerland) vol. 9,3 (2019). doi: https://doi.org/10.3390/nano9030380
Rafael D, Andrade F, Martinez-Trucharte F, Basas J, Seras-Franzoso J, Palau M, Gomis X, Pérez-Burgos M, Blanco A, López-Fernández A, Vélez R, Abasolo I, Aguirre M, Gavaldà J, Schwartz S. Sterilization Procedure for Temperature-Sensitive Hydrogels Loaded with Silver Nanoparticles for Clinical Applications. Nanomaterials (Basel). 2019 Mar 06;9(3). doi: 10.3390/nano9030380. PMID: 30845683; PMCID: PMC6474025.
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Nanomaterials (Basel). 2019 Mar 06;9(3). doi: 10.3390/nano9030380.

Sterilization Procedure for Temperature-Sensitive Hydrogels Loaded with Silver Nanoparticles for Clinical Applications.

Nanomaterials (Basel, Switzerland)

Diana Rafael, Fernanda Andrade, Francesc Martinez-Trucharte, Jana Basas, Joaquín Seras-Franzoso, Marta Palau, Xavier Gomis, Marc Pérez-Burgos, Alberto Blanco, Alba López-Fernández, Roberto Vélez, Ibane Abasolo, Màrius Aguirre, Joan Gavaldà, Simó Schwartz

Affiliations

  1. Drug Delivery and Targeting Group, Molecular Biology and Biochemistry Research Centre for Nanomedicine (CIBBIM-Nanomedicine), Vall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona (UAB), 08035 Barcelona, Spain. [email protected].
  2. Networking Research Centre for Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Instituto de Salud Carlos III, 28029 Madrid, Spain. [email protected].
  3. Drug Delivery and Targeting Group, Molecular Biology and Biochemistry Research Centre for Nanomedicine (CIBBIM-Nanomedicine), Vall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona (UAB), 08035 Barcelona, Spain. [email protected].
  4. i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen 208, 4200-180 Porto, Portugal. [email protected].
  5. INEB-Instituto Nacional de Engenharia Biomédica, Universidade do Porto, Rua Alfredo Allen 208, 4200-180 Porto, Portugal. [email protected].
  6. Drug Delivery and Targeting Group, Molecular Biology and Biochemistry Research Centre for Nanomedicine (CIBBIM-Nanomedicine), Vall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona (UAB), 08035 Barcelona, Spain. [email protected].
  7. Antimicrobial Resistance Laboratory, Vall d'Hebron Research Institute (VHIR), Department of Infectious Diseases, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain. [email protected].
  8. Spanish Network for Research in Infectious Diseases (REIPI RD16/0016/0003), Instituto de Salud Carlos III, 28029 Madrid, Spain. [email protected].
  9. Drug Delivery and Targeting Group, Molecular Biology and Biochemistry Research Centre for Nanomedicine (CIBBIM-Nanomedicine), Vall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona (UAB), 08035 Barcelona, Spain. [email protected].
  10. Antimicrobial Resistance Laboratory, Vall d'Hebron Research Institute (VHIR), Department of Infectious Diseases, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain. [email protected].
  11. Spanish Network for Research in Infectious Diseases (REIPI RD16/0016/0003), Instituto de Salud Carlos III, 28029 Madrid, Spain. [email protected].
  12. Antimicrobial Resistance Laboratory, Vall d'Hebron Research Institute (VHIR), Department of Infectious Diseases, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain. [email protected].
  13. Drug Delivery and Targeting Group, Molecular Biology and Biochemistry Research Centre for Nanomedicine (CIBBIM-Nanomedicine), Vall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona (UAB), 08035 Barcelona, Spain. [email protected].
  14. Orthopedic Surgery Department, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona (UAB), 08035 Barcelona, Spain. [email protected].
  15. Musculoskeletal Tissue Engineering Group, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona (UAB), Passeig de la Vall d'Hebron 129-139, 08035 Barcelona, Spain. [email protected].
  16. Musculoskeletal Tissue Engineering Group, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona (UAB), Passeig de la Vall d'Hebron 129-139, 08035 Barcelona, Spain. [email protected].
  17. Orthopedic Surgery Department, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona (UAB), 08035 Barcelona, Spain. [email protected].
  18. Musculoskeletal Tissue Engineering Group, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona (UAB), Passeig de la Vall d'Hebron 129-139, 08035 Barcelona, Spain. [email protected].
  19. Drug Delivery and Targeting Group, Molecular Biology and Biochemistry Research Centre for Nanomedicine (CIBBIM-Nanomedicine), Vall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona (UAB), 08035 Barcelona, Spain. [email protected].
  20. Networking Research Centre for Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Instituto de Salud Carlos III, 28029 Madrid, Spain. [email protected].
  21. Orthopedic Surgery Department, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona (UAB), 08035 Barcelona, Spain. [email protected].
  22. Antimicrobial Resistance Laboratory, Vall d'Hebron Research Institute (VHIR), Department of Infectious Diseases, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain. [email protected].
  23. Spanish Network for Research in Infectious Diseases (REIPI RD16/0016/0003), Instituto de Salud Carlos III, 28029 Madrid, Spain. [email protected].
  24. Drug Delivery and Targeting Group, Molecular Biology and Biochemistry Research Centre for Nanomedicine (CIBBIM-Nanomedicine), Vall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona (UAB), 08035 Barcelona, Spain. [email protected].
  25. Networking Research Centre for Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Instituto de Salud Carlos III, 28029 Madrid, Spain. [email protected].

PMID: 30845683 PMCID: PMC6474025 DOI: 10.3390/nano9030380

Abstract

Hydrogels (HG) have recognized benefits as drug delivery platforms for biomedical applications. Their high sensitivity to sterilization processes is however one of the greatest challenges regarding their clinical translation. Concerning infection diseases, prevention of post-operatory related infections is crucial to ensure appropriate patient recovery and good clinical outcomes. Silver nanoparticles (AgNPs) have shown good antimicrobial properties but sustained release at the right place is required. Thus, we produced and characterized thermo-sensitive HG based on Pluronic

Keywords: XDR strains; anti-bacterial agents; chirurgic applications; hydrogels; poloxamer; post-operative infections; silver nanoparticles; sterilization

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