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Mura M, Ruffié C, Combredet C, et al. Recombinant measles vaccine expressing malaria antigens induces long-term memory and protection in mice. NPJ Vaccines. 2019;4:12doi: 10.1038/s41541-019-0106-8.
Mura, M., Ruffié, C., Combredet, C., Aliprandini, E., Formaglio, P., Chitnis, C. E., Amino, R., & Tangy, F. (2019). Recombinant measles vaccine expressing malaria antigens induces long-term memory and protection in mice. NPJ vaccines, 412. https://doi.org/10.1038/s41541-019-0106-8
Mura, Marie, et al. "Recombinant measles vaccine expressing malaria antigens induces long-term memory and protection in mice." NPJ vaccines vol. 4 (2019): 12. doi: https://doi.org/10.1038/s41541-019-0106-8
Mura M, Ruffié C, Combredet C, Aliprandini E, Formaglio P, Chitnis CE, Amino R, Tangy F. Recombinant measles vaccine expressing malaria antigens induces long-term memory and protection in mice. NPJ Vaccines. 2019 Feb 27;4:12. doi: 10.1038/s41541-019-0106-8. eCollection 2019. PMID: 30820355; PMCID: PMC6393439.
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NPJ Vaccines. 2019 Feb 27;4:12. doi: 10.1038/s41541-019-0106-8. eCollection 2019.

Recombinant measles vaccine expressing malaria antigens induces long-term memory and protection in mice.

NPJ vaccines

Marie Mura, Claude Ruffié, Chantal Combredet, Eduardo Aliprandini, Pauline Formaglio, Chetan E Chitnis, Rogerio Amino, Frédéric Tangy

Affiliations

  1. 1Viral Genomics and Vaccination, Institut Pasteur, CNRS UMR-3569, 28 rue du Dr Roux, 75015 Paris, France.
  2. 2Anti-infectious Biotherapies and Immunity, Institut de Recherche Biomédicale des Armées, 1 place du Général Valérie André, BP73 Brétigny-sur-Orge Cedex, France.
  3. 3Malaria Infection and Immunity, Institut Pasteur, CNRS UMR-3569, 28 rue du Dr Roux, 75015 Paris, France.
  4. 4Malaria Parasite Biology and Vaccines, Institut Pasteur, CNRS UMR-3569, 28 rue du Dr Roux, 75015 Paris, France.

PMID: 30820355 PMCID: PMC6393439 DOI: 10.1038/s41541-019-0106-8

Abstract

Following the RTS,S malaria vaccine, which showed only partial protection with short-term memory, there is strong support to develop second-generation malaria vaccines that yield higher efficacy with longer duration. The use of replicating viral vectors to deliver subunit vaccines is of great interest due to their capacity to induce efficient cellular immune responses and long-term memory. The measles vaccine virus offers an efficient and safe live viral vector that could easily be implemented in the field. Here, we produced recombinant measles viruses (rMV) expressing malaria "gold standard" circumsporozoïte antigen (CS) of

Conflict of interest statement

The authors declare no competing interests.

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