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Roshankhah S, Jalili C, Salahshoor MR. Effects of Crocin on Sperm Parameters and Seminiferous Tubules in Diabetic Rats. Adv Biomed Res. 2019;8:4doi: 10.4103/abr.abr_124_18.
Roshankhah, S., Jalili, C., & Salahshoor, M. R. (2019). Effects of Crocin on Sperm Parameters and Seminiferous Tubules in Diabetic Rats. Advanced biomedical research, 84. https://doi.org/10.4103/abr.abr_124_18
Roshankhah, Shiva, et al. "Effects of Crocin on Sperm Parameters and Seminiferous Tubules in Diabetic Rats." Advanced biomedical research vol. 8 (2019): 4. doi: https://doi.org/10.4103/abr.abr_124_18
Roshankhah S, Jalili C, Salahshoor MR. Effects of Crocin on Sperm Parameters and Seminiferous Tubules in Diabetic Rats. Adv Biomed Res. 2019 Jan 31;8:4. doi: 10.4103/abr.abr_124_18. eCollection 2019. PMID: 30820425; PMCID: PMC6385561.
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Adv Biomed Res. 2019 Jan 31;8:4. doi: 10.4103/abr.abr_124_18. eCollection 2019.

Effects of Crocin on Sperm Parameters and Seminiferous Tubules in Diabetic Rats.

Advanced biomedical research

Shiva Roshankhah, Cyrus Jalili, Mohammad Reza Salahshoor

Affiliations

  1. Department of Anatomical Sciences, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran.
  2. Department of Anatomical Sciences, Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.

PMID: 30820425 PMCID: PMC6385561 DOI: 10.4103/abr.abr_124_18

Abstract

BACKGROUND: Diabetes can increase the generation of free radicals and can be harmfully effective in spermatogenesis. Crocin is a carotenoid and is accountable for the red color of saffron. Crocin has shown numerous pharmacological actions such as antioxidant roles and radical scavenging. The aim of this study was to determine the effects of crocin on sperm parameters and the diameter of seminiferous tubules in diabetic rats.

MATERIALS AND METHODS: In this experimental study, diabetic rats were induced by Streptozotocin (STZ) (60 mg/kg). Sixty-four rats were equally divided into the following eight groups; (1) normal control group, (2-4) crocin groups, receiving various doses of crocin (12.5, 25, and 50 mg/kg), (5) diabetic control group, and (6-8) diabetic groups, receiving STZ plus crocin (12.5, 25, and 50 mg/kg) injected intraperitoneally once a day for 28 consecutive days. The sperm count, motility, morphology, viability, spermatogenesis index (SI), and the diameter of seminiferous tubules were examined and compared.

RESULTS: The results demonstrated that count, motility, viability, normal sperm morphology, SI, and the diameter of seminiferous tubules decreased significantly in the diabetic control group compared to the normal control group (

CONCLUSION: It seems that, as a strong antioxidant, crocin could compensate for the toxicity induced through STZ and raise the quality of some sperm parameters.

Keywords: Crocin; diabetes; seminiferous tubules; sperm parameters

Conflict of interest statement

There are no conflicts of interest.

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