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Neurobiol Stress. 2018 Dec 19;10:100143. doi: 10.1016/j.ynstr.2018.100143. eCollection 2019 Feb.

Sex-associated differences in excitability within the bed nucleus of the stria terminalis are reflective of cell-type.

Neurobiology of stress

Hannah E Smithers, John R Terry, Jonathan T Brown, Andrew D Randall

Affiliations

  1. Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Hatherly Laboratory, Exeter, EX4 4PS, UK.
  2. College of Engineering, Mathematics and Physical Sciences, University of Exeter, Living Systems Institute, EX4 4QD, UK.

PMID: 30937349 PMCID: PMC6430407 DOI: 10.1016/j.ynstr.2018.100143

Abstract

The bed nucleus of the stria terminalis (BNST) is a sexually dimorphic brain region which plays a key role in stress, anxiety, and anxiety-related disorders. Human females have an increased susceptibility to anxiety-related disorders, however the physiological basis of this is not fully understood. Here we examined the effect of the oestrous cycle and sex on the electrophysiological properties of Type I and Type II cells in the anterolateral area of the BNST (BNST

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