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Manzano BR, Santaella NG, Oliveira MA, et al. Retrospective study of osteoradionecrosis in the jaws of patients with head and neck cancer. J Korean Assoc Oral Maxillofac Surg. 2019;45(1):21-28doi: 10.5125/jkaoms.2019.45.1.21.
Manzano, B. R., Santaella, N. G., Oliveira, M. A., Rubira, C. M. F., & Santos, P. S. D. S. (2019). Retrospective study of osteoradionecrosis in the jaws of patients with head and neck cancer. Journal of the Korean Association of Oral and Maxillofacial Surgeons, 45(1), 21-28. https://doi.org/10.5125/jkaoms.2019.45.1.21
Manzano, Brena Rodrigues, et al. "Retrospective study of osteoradionecrosis in the jaws of patients with head and neck cancer." Journal of the Korean Association of Oral and Maxillofacial Surgeons vol. 45,1 (2019): 21-28. doi: https://doi.org/10.5125/jkaoms.2019.45.1.21
Manzano BR, Santaella NG, Oliveira MA, Rubira CMF, Santos PSDS. Retrospective study of osteoradionecrosis in the jaws of patients with head and neck cancer. J Korean Assoc Oral Maxillofac Surg. 2019 Feb;45(1):21-28. doi: 10.5125/jkaoms.2019.45.1.21. Epub 2019 Feb 26. PMID: 30847293; PMCID: PMC6400702.
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J Korean Assoc Oral Maxillofac Surg. 2019 Feb;45(1):21-28. doi: 10.5125/jkaoms.2019.45.1.21. Epub 2019 Feb 26.

Retrospective study of osteoradionecrosis in the jaws of patients with head and neck cancer.

Journal of the Korean Association of Oral and Maxillofacial Surgeons

Brena Rodrigues Manzano, Natália Garcia Santaella, Marco Aurélio Oliveira, Cássia Maria Fischer Rubira, Paulo Sérgio da Silva Santos

Affiliations

  1. Departament of Surgery, Stomatology, Pathology and Radiology, Bauru School of Dentistry, University of São Paulo, Bauru, Brazil.

PMID: 30847293 PMCID: PMC6400702 DOI: 10.5125/jkaoms.2019.45.1.21

Abstract

OBJECTIVES: Osteoradionecrosis (ORN) is one of the most severe complications resulting from radiotherapy (RT) in patients with head and neck cancer (HNC). It is characterized by persistent exposed and devitalized bone without proper healing for greater than 6 months after a high dose of radiation in the area. To describe the profile and dental management of ORN in HNC patients undergoing RT in an oncological clinical research center.

MATERIALS AND METHODS: A retrospective descriptive study was performed to analyze dental records from HNC patients with ORN treated at an oncological clinical research center from 2013 to 2017. A total of 158 dental records for HNC patients were selected from a total of 583 records. Afterwards, this number was distributed to three examiners for manual assessments. Each examiner was responsible for selecting dental records that contained an ORN description, resulting in 20 dental records.

RESULTS: Mean patient age was 60.3 years with males being the most affected sex (80.0%). The most affected area was the posterior region of the mandible (60.0%) followed by the anterior region of the mandible (20.0%) and the posterior region of the maxilla (10.0%). The factors most associated with ORN were dental conditions (70.0%) followed by isolated systemic factors (10.0%) and tumor resection (5.0%). There was total exposed bone closure in 50.0% of cases. The predominant treatment was curettage associated with chlorhexidine 0.12% irrigation (36.0%).

CONCLUSION: Poor dental conditions were related to ORN occurrence. ORN management through less invasive therapies was effective for the closure of exposed bone areas and avoidance of infection.

Keywords: Conservative treatment; Head and neck neoplasms; Mandible; Maxilla; Osteoradionecrosis

Conflict of interest statement

Conflict of Interest: No potential conflict of interest relevant to this article was reported.

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