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Eken SM, Christersdottir T, Winski G, et al. miR-29b Mediates the Chronic Inflammatory Response in Radiotherapy-Induced Vascular Disease. JACC Basic Transl Sci. 2019;4(1):72-82doi: 10.1016/j.jacbts.2018.10.006.
Eken, S. M., Christersdottir, T., Winski, G., Sangsuwan, T., Jin, H., Chernogubova, E., Pirault, J., Sun, C., Simon, N., Winter, H., Backlund, A., Haghdoost, S., Hansson, G. K., Halle, M., & Maegdefessel, L. (2019). miR-29b Mediates the Chronic Inflammatory Response in Radiotherapy-Induced Vascular Disease. JACC. Basic to translational science, 4(1), 72-82. https://doi.org/10.1016/j.jacbts.2018.10.006
Eken, Suzanne M, et al. "miR-29b Mediates the Chronic Inflammatory Response in Radiotherapy-Induced Vascular Disease." JACC. Basic to translational science vol. 4,1 (2019): 72-82. doi: https://doi.org/10.1016/j.jacbts.2018.10.006
Eken SM, Christersdottir T, Winski G, Sangsuwan T, Jin H, Chernogubova E, Pirault J, Sun C, Simon N, Winter H, Backlund A, Haghdoost S, Hansson GK, Halle M, Maegdefessel L. miR-29b Mediates the Chronic Inflammatory Response in Radiotherapy-Induced Vascular Disease. JACC Basic Transl Sci. 2019 Feb 25;4(1):72-82. doi: 10.1016/j.jacbts.2018.10.006. eCollection 2019 Feb. PMID: 30847421; PMCID: PMC6390501.
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JACC Basic Transl Sci. 2019 Feb 25;4(1):72-82. doi: 10.1016/j.jacbts.2018.10.006. eCollection 2019 Feb.

miR-29b Mediates the Chronic Inflammatory Response in Radiotherapy-Induced Vascular Disease.

JACC. Basic to translational science

Suzanne M Eken, Tinna Christersdottir, Greg Winski, Traimate Sangsuwan, Hong Jin, Ekaterina Chernogubova, John Pirault, Changyan Sun, Nancy Simon, Hanna Winter, Alexandra Backlund, Siamak Haghdoost, Göran K Hansson, Martin Halle, Lars Maegdefessel

Affiliations

  1. Cardiovascular Medicine Unit, Department of Medicine, Solna, Karolinska Institute, Stockholm, Sweden.
  2. Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
  3. Department of Molecular Biosciences, Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
  4. INSERM UMR_S1116, Université de Lorraine, Vandoeuvre-lès-Nancy, France.
  5. Technical University Munich, Department of Vascular and Endovascular Surgery, Munich, Germany.
  6. German Center for Cardiovascular Research (DZHK) partner site Munich, Munich, Germany.
  7. University of Caen Normandie, LARIA-CIMAP, Caen, France.
  8. Department of Reconstructive Plastic Surgery, Karolinska University Hospital, Stockholm, Sweden.

PMID: 30847421 PMCID: PMC6390501 DOI: 10.1016/j.jacbts.2018.10.006

Abstract

As a consequence of the success of present-day cancer treatment, radiotherapy-induced vascular disease is emerging. This disease is caused by chronic inflammatory activation and is likely orchestrated in part by microRNAs. In irradiated versus nonirradiated conduit arteries from patients receiving microvascular free tissue transfer reconstructions, irradiation resulted in down-regulation of miR-29b and up-regulation of miR-146b. miR-29b affected inflammation and adverse wound healing through its targets pentraxin-3 and dipeptidyl-peptidase 4. In vitro and in vivo, we showed that miR-29b overexpression therapy, through inhibition of pentraxin-3 and dipeptidyl-peptidase 4, could dampen the vascular inflammatory response.

Keywords: Apoe–/–, apolipoprotein E knockout; DIG, digoxigenin; DPP4, Dpp4, dipeptidyl-peptidase 4; FFT, free flap tissue transfer; HCtAEC, human carotid artery endothelial cell; HCtASMC, human carotid artery smooth muscle cell; NR, nonirradiated; PTX3, Ptx3, pentraxin-3; RNA, ribonucleic acid; SMC, smooth muscle cell; TGF, tumor growth factor; arteriosclerosis; inflammation; mRNA, messenger ribonucleic acid; miRNA, microRNA; microRNA; radiotherapy; vRTx, radiation vasculopathy

References

  1. FASEB J. 2001 Jul;15(9):1546-54 - PubMed
  2. Eur J Cancer. 2002 Mar;38(5):667-73 - PubMed
  3. BMJ. 2003 Feb 1;326(7383):256-7 - PubMed
  4. Lancet Oncol. 2003 Sep;4(9):529-36 - PubMed
  5. Oral Oncol. 2004 Oct;40(9):872-8 - PubMed
  6. Am J Pathol. 2006 Feb;168(2):649-58 - PubMed
  7. J Clin Immunol. 2008 Jan;28(1):1-13 - PubMed
  8. J Plast Reconstr Aesthet Surg. 2009 Jul;62(7):889-95 - PubMed
  9. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13027-32 - PubMed
  10. Cell. 2009 Jan 23;136(2):215-33 - PubMed
  11. Annu Rev Immunol. 2010;28:157-83 - PubMed
  12. J Am Coll Cardiol. 2010 Mar 23;55(12):1227-36 - PubMed
  13. Radiat Oncol. 2010 Mar 26;5:25 - PubMed
  14. Plast Reconstr Surg. 2011 Feb;127(2):496-504 - PubMed
  15. Nucleic Acids Res. 2011 Jan;39(Database issue):D163-9 - PubMed
  16. J Cardiovasc Pharmacol. 2011 Aug;58(2):157-66 - PubMed
  17. Nature. 2011 May 19;473(7347):317-25 - PubMed
  18. Trends Biochem Sci. 2011 Sep;36(9):478-84 - PubMed
  19. Stroke. 2011 Sep;42(9):2410-8 - PubMed
  20. J Clin Oncol. 2012 Feb 1;30(4):380-6 - PubMed
  21. Physiol Genomics. 2012 Feb 27;44(4):237-44 - PubMed
  22. J Clin Invest. 2012 Feb;122(2):497-506 - PubMed
  23. PLoS One. 2012;7(2):e32794 - PubMed
  24. Cell. 2012 Apr 27;149(3):515-24 - PubMed
  25. Nat Rev Drug Discov. 2012 Nov;11(11):860-72 - PubMed
  26. N Engl J Med. 2013 Mar 14;368(11):987-98 - PubMed
  27. N Engl J Med. 2013 May 2;368(18):1685-94 - PubMed
  28. J Am Coll Cardiol. 2013 Jun 11;61(23):2319-28 - PubMed
  29. Eur Heart J. 2014 Mar;35(10):612-23 - PubMed
  30. EMBO Mol Med. 2013 Jul;5(7):1017-34 - PubMed
  31. Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11499-504 - PubMed
  32. Circ Res. 2013 Oct 25;113(10):1138-47 - PubMed
  33. Radiother Oncol. 2014 Jan;110(1):31-8 - PubMed
  34. J Transl Med. 2013 Sep 23;11:223 - PubMed
  35. CA Cancer J Clin. 2014 Jul-Aug;64(4):252-71 - PubMed
  36. Ann Plast Surg. 2015 Sep;75(3):309-15 - PubMed
  37. PLoS One. 2014 Oct 16;9(10):e110389 - PubMed
  38. ANZ J Surg. 2015 Mar;85(3):121-7 - PubMed
  39. J Clin Invest. 2015 Jan;125(1):141-56 - PubMed
  40. Circ Res. 2015 Feb 27;116(5):816-26 - PubMed
  41. Oncotarget. 2015 Jan 20;6(2):1101-14 - PubMed
  42. J Am Heart Assoc. 2015 Mar 13;4(3):e001469 - PubMed
  43. Nat Rev Cardiol. 2015 Jun;12(6):361-74 - PubMed
  44. Circ Res. 2015 Apr 10;116(8):1491-504 - PubMed
  45. Science. 2015 Apr 17;348(6232):aaa2151 - PubMed
  46. Clin Geriatr Med. 2016 Feb;32(1):63-80 - PubMed
  47. Curr Opin Immunol. 2016 Feb;38:39-44 - PubMed
  48. Fibrogenesis Tissue Repair. 2016 Feb 13;9:1 - PubMed
  49. EMBO Mol Med. 2016 Jun 01;8(6):643-53 - PubMed
  50. Sci Transl Med. 2018 Jan 24;10(425): - PubMed
  51. Int J Radiat Biol. 1998 Apr;73(4):401-8 - PubMed

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