Display options
Cite
Rau JC, Dodick DW. Other Preventive Anti-Migraine Treatments: ACE Inhibitors, ARBs, Calcium Channel Blockers, Serotonin Antagonists, and NMDA Receptor Antagonists. Curr Treat Options Neurol. 2019;21(4):17doi: 10.1007/s11940-019-0559-0.
Rau, J. C., & Dodick, D. W. (2019). Other Preventive Anti-Migraine Treatments: ACE Inhibitors, ARBs, Calcium Channel Blockers, Serotonin Antagonists, and NMDA Receptor Antagonists. Current treatment options in neurology, 21(4), 17. https://doi.org/10.1007/s11940-019-0559-0
Rau, Jill C, and Dodick, David W. "Other Preventive Anti-Migraine Treatments: ACE Inhibitors, ARBs, Calcium Channel Blockers, Serotonin Antagonists, and NMDA Receptor Antagonists." Current treatment options in neurology vol. 21,4 (2019): 17. doi: https://doi.org/10.1007/s11940-019-0559-0
Rau JC, Dodick DW. Other Preventive Anti-Migraine Treatments: ACE Inhibitors, ARBs, Calcium Channel Blockers, Serotonin Antagonists, and NMDA Receptor Antagonists. Curr Treat Options Neurol. 2019 Mar 18;21(4):17. doi: 10.1007/s11940-019-0559-0. PMID: 30880363.
Copy Download .nbib Format: NLM
Share it on

Curr Treat Options Neurol. 2019 Mar 18;21(4):17. doi: 10.1007/s11940-019-0559-0.

Other Preventive Anti-Migraine Treatments: ACE Inhibitors, ARBs, Calcium Channel Blockers, Serotonin Antagonists, and NMDA Receptor Antagonists.

Current treatment options in neurology

Jill C Rau, David W Dodick

Affiliations

  1. Mayo Clinic, 13400 E. Shea Blvd., Scottsdale, AZ, 85259, USA.
  2. Mayo Clinic, 13400 E. Shea Blvd., Scottsdale, AZ, 85259, USA. [email protected].

PMID: 30880363 DOI: 10.1007/s11940-019-0559-0

Abstract

PURPOSE OF REVIEW: Migraine causes more years of life lived with disability than almost any other condition in the world and can significantly impact the lives of individuals with migraine, their families, and society. The use of medication for the prevention of migraine is an integral component to reducing disability caused by migraine. There are many different drug classes that have been investigated and shown efficacy in migraine prophylaxis. This article examines several of the classes of medications that are used for migraine preventive treatment, specifically, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, calcium channel blockers, serotonin antagonists, alpha-adrenergic agonists, and N-methyl-D-aspartic acid receptor antagonists.

RECENT FINDINGS: There have been randomized control trials investigating medications in these drug classes since the most recent guidelines for migraine prevention in adults were published by the American Academy of Neurology, American Headache Society, and the Canadian Headache Society. In these investigations, enalapril, candesartan, and memantine all demonstrated efficacy for migraine prevention. The evidence for these and the aforementioned drug classes are reviewed. When oral medications are being selected for migraine prevention, comorbid and coexistent medical conditions, concomitant medications, patient preference, and pregnancy and breast-feeding plans should be considered. Within the drug classes discussed, memantine and candesartan have a moderate level of evidence for efficacy.

Keywords: Adult; Medications; Migraine; Prevention

References

  1. Arch Intern Med. 1999 Apr 26;159(8):813-8 - PubMed
  2. Ugeskr Laeger. 1975 Jan 13;137(3):149-51 - PubMed
  3. Curr Med Res Opin. 1975;3(2):68-71 - PubMed
  4. Headache. 1975 Oct;15(3):202-10 - PubMed
  5. Neurol India. 2000 Sep;48(3):223-6 - PubMed
  6. BMJ. 2001 Jan 6;322(7277):19-22 - PubMed
  7. J Pharmacol Exp Ther. 2002 Jan;300(1):282-90 - PubMed
  8. Am J Physiol Regul Integr Comp Physiol. 2002 Aug;283(2):R287-95 - PubMed
  9. Headache. 2002 Jun;42(6):470-82 - PubMed
  10. Anesthesiology. 2002 Oct;97(4):972-80 - PubMed
  11. JAMA. 2003 Jan 1;289(1):65-9 - PubMed
  12. Rev Neurol. 2003 May 16-31;36(10):907-12 - PubMed
  13. Headache. 1992 Oct;32(9):461-2 - PubMed
  14. Clin Ter. 1992 Dec;141(12):475-81 - PubMed
  15. Headache. 1979 May;19(4):219-22 - PubMed
  16. Ann Neurol. 2006 Apr;59(4):652-61 - PubMed
  17. Headache. 2006 Jun;46 Suppl 1:S39-44 - PubMed
  18. Neurology. 2007 Jan 30;68(5):343-9 - PubMed
  19. Neurol Sci. 2007 May;28 Suppl 2:S70-7 - PubMed
  20. Headache. 1991 Oct;31(9):613-5 - PubMed
  21. Eur J Clin Pharmacol. 1991;41(1):69-71 - PubMed
  22. Headache. 2007 Sep;47(8):1178-83 - PubMed
  23. Eur J Pharmacol. 1991 May 17;197(2-3):221-3 - PubMed
  24. Cephalalgia. 2009 Sep;29(9):921-7 - PubMed
  25. Neurol Clin. 2009 May;27(2):445-65 - PubMed
  26. Cephalalgia. 2009 Oct;29(10):1115-24 - PubMed
  27. Cephalalgia. 1991 Feb;11(1):37-45 - PubMed
  28. Headache. 1990 Nov;30(11):710-5 - PubMed
  29. Clin Ter. 1990 Jul 31;134(2):119-25 - PubMed
  30. Headache. 2011 Sep;51(8):1323-35 - PubMed
  31. Headache. 2011 Sep;51(8):1336-45 - PubMed
  32. Curr Treat Options Neurol. 2012 Feb;14(1):27-35 - PubMed
  33. Cephalalgia. 1990 Jun;10(3):111-6 - PubMed
  34. Neurology. 2012 Apr 24;78(17):1337-45 - PubMed
  35. Can J Neurol Sci. 2012 Mar;39(2 Suppl 2):S1-59 - PubMed
  36. Biochim Biophys Acta. 2013 Jul;1828(7):1655-65 - PubMed
  37. Curr Treat Options Neurol. 2013 Feb;15(1):13-27 - PubMed
  38. Int J Prev Med. 2013 Jan;4(1):72-7 - PubMed
  39. Headache. 2013 Mar;53(3):427-36 - PubMed
  40. Cephalalgia. 2014 Feb;34(2):86-9 - PubMed
  41. Eur Arch Otorhinolaryngol. 2014 Nov;271(11):2931-6 - PubMed
  42. Cephalalgia. 2014 Jun;34(7):523-32 - PubMed
  43. Expert Rev Neurother. 2014 Sep;14(9):1043-55 - PubMed
  44. PLoS One. 2015 Jul 14;10(7):e0130733 - PubMed
  45. Acta Otorhinolaryngol Ital. 2015 Jun;35(3):135-45 - PubMed
  46. Neurology. 1989 Feb;39(2 Pt 1):284-6 - PubMed
  47. Headache. 1989 Apr;29(4):215-8 - PubMed
  48. Headache. 2016 Jan;56(1):95-103 - PubMed
  49. J Fam Pract. 1989 Aug;29(2):153-6; discussion 157-8 - PubMed
  50. Headache. 1989 Nov;29(10):633-8 - PubMed
  51. Headache. 1989 Nov;29(10):639-42 - PubMed
  52. Neurology. 2016 May 10;86(19):1818-26 - PubMed
  53. Neuropharmacology. 2017 Apr;116:160-173 - PubMed
  54. Neurology. 2017 Apr 25;88(17):1634-1641 - PubMed
  55. Eur J Neurol. 2017 Jul;24(7):883-891 - PubMed
  56. BMJ Open. 2017 Aug 11;7(8):e016670 - PubMed
  57. Headache. 2018 Jan;58(1):184-193 - PubMed
  58. Front Neurol. 2017 Oct 11;8:524 - PubMed
  59. Lancet Neurol. 2018 Feb;17(2):174-182 - PubMed
  60. Neurotherapeutics. 2018 Apr;15(2):361-370 - PubMed
  61. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 May 20;30(10):805-810 - PubMed
  62. Curr Pain Headache Rep. 2018 Jul 16;22(9):61 - PubMed
  63. Curr Pain Headache Rep. 2018 Jul 30;22(10):65 - PubMed
  64. J Pharmacol Exp Ther. 2019 Apr;369(1):26-36 - PubMed
  65. Cephalalgia. 1988 Dec;8(4):269-72 - PubMed
  66. Cephalalgia. 2019 Mar;39(3):445-458 - PubMed
  67. Headache. 1988 May;28(4):260-2 - PubMed
  68. Headache. 1977 Mar;17(1):28-31 - PubMed
  69. Acta Neurol Scand. 1977 Jul;56(1):17-28 - PubMed
  70. Headache. 1977 Jul;17(3):109-12 - PubMed
  71. Acta Neurol Scand. 1977 Nov;56(5):405-12 - PubMed
  72. Headache. 1986 Feb;26(2):83-5 - PubMed
  73. Cephalalgia. 1986 Mar;6(1):15-8 - PubMed
  74. Cephalalgia. 1986 Mar;6(1):7-14 - PubMed
  75. Headache. 1987 Feb;27(2):76-9 - PubMed
  76. Cephalalgia. 1987 Mar;7(1):7-13 - PubMed
  77. Acta Neurol Scand. 1978 Nov;58(5):288-95 - PubMed
  78. J R Coll Gen Pract. 1978 Oct;28(195):587-90 - PubMed
  79. Cephalalgia. 1985 Mar;5(1):39-43 - PubMed
  80. Cephalalgia. 1985 May;5 Suppl 2:135-40 - PubMed
  81. Cephalalgia. 1985 Sep;5(3):159-65 - PubMed
  82. Acta Neurol Scand. 1979 Oct;60(4):214-7 - PubMed
  83. Int J Clin Pharmacol Res. 1986;6(1):27-32 - PubMed
  84. Cephalalgia. 1985 May;5 Suppl 2:173-5 - PubMed
  85. Br J Obstet Gynaecol. 1985 Nov;92(11):1169-75 - PubMed
  86. Lancet. 1972 Feb 19;1(7747):403-7 - PubMed
  87. Med J Aust. 1972 Jun 24;1(26):1343-6 - PubMed
  88. Psychosomatics. 1973 Sep-Oct;14(5):302-8 - PubMed
  89. Med J Aust. 1968 Jan 13;1(2):54-5 - PubMed
  90. Headache. 1968 Oct;8(3):118-26 - PubMed
  91. Acta Neurol Scand. 1969;45(5):594-600 - PubMed
  92. N Z Med J. 1971 Jan;73(464):5-9 - PubMed
  93. Acta Neurol Scand. 1971;47(1):120-2 - PubMed
  94. Res Clin Stud Headache. 1970;3:315-20 - PubMed
  95. Curr Ther Res Clin Exp. 1971 Jan;13(1):63-8 - PubMed
  96. Headache. 1971 Apr;11(1):6-18 - PubMed
  97. Dev Med Child Neurol. 1982 Dec;24(6):837-41 - PubMed
  98. Clin Neurol Neurosurg. 1984;86(1):17-20 - PubMed
  99. N Engl J Med. 1983 May 5;308(18):1102-3 - PubMed
  100. Headache. 1983 May;23(3):106-9 - PubMed
  101. JAMA. 1983 Nov 11;250(18):2500-2 - PubMed
  102. Neurology. 1984 Jul;34(7):973-6 - PubMed
  103. Cephalalgia. 1982 Dec;2(4):197-203 - PubMed
  104. Acta Neurol Scand. 1980 Jun;61(6):351-6 - PubMed
  105. Headache. 1981 Nov;21(6):235-9 - PubMed
  106. Acta Neurol Scand. 1976 Mar;53(3):233-6 - PubMed
  107. Cephalalgia. 1994 Jun;14(3):235-40 - PubMed
  108. Cephalalgia. 1993 Apr;13(2):89-93 - PubMed
  109. Headache. 1993 Jun;33(6):335-8 - PubMed
  110. Cephalalgia. 1995 Dec;15(6):489-93 - PubMed
  111. J Assoc Physicians India. 1995 Nov;43(11):770-2 - PubMed
  112. Cell. 1996 Nov 1;87(3):543-52 - PubMed
  113. Headache. 1977 Sep;17(4):169-72 - PubMed
  114. Eur Neurol. 1997;38(1):31-8 - PubMed

Publication Types