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Engidaye G, Melku M, Enawgaw B. Diamond Blackfan Anemia: Genetics, Pathogenesis, Diagnosis and Treatment. EJIFCC. 2019;30(1):67-81
Engidaye, G., Melku, M., & Enawgaw, B. (2019). Diamond Blackfan Anemia: Genetics, Pathogenesis, Diagnosis and Treatment. EJIFCC, 30(1), 67-81.
Engidaye, Getabalew, et al. "Diamond Blackfan Anemia: Genetics, Pathogenesis, Diagnosis and Treatment." EJIFCC vol. 30,1 (2019): 67-81.
Engidaye G, Melku M, Enawgaw B. Diamond Blackfan Anemia: Genetics, Pathogenesis, Diagnosis and Treatment. EJIFCC. 2019 Mar 01;30(1):67-81. eCollection 2019 Mar. PMID: 30881276; PMCID: PMC6416817.
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EJIFCC. 2019 Mar 01;30(1):67-81. eCollection 2019 Mar.

Diamond Blackfan Anemia: Genetics, Pathogenesis, Diagnosis and Treatment.

EJIFCC

Getabalew Engidaye, Mulugeta Melku, Bamlaku Enawgaw

Affiliations

  1. Amhara Regional State Debre Berhan Health Science College, Debre Berhan, Ethiopia.
  2. Department of Hematology & Immunohematology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Ethiopia.

PMID: 30881276 PMCID: PMC6416817

Abstract

Diamond Blackfan Anaemia (DBA) is a sporadic inherited anemia with broad spectrum of anomalies that are presented soon after delivery. It is inherited mainly in autosomal dominant inheritance manner and caused by mutations and deletions in either large or small ribosomal protein genes that results in an imbalance between the biosynthesis of rRNA and ribosomal proteins, eventually the activation and stabilization of p53. Diagnosing DBA is usually problematic due to a partial phenotype and its wide inconsistency in its clinical expression; however, molecular studies have identified a heterozygous mutated gene in up to 50% of the DBA cases and corticosteroid drugs are the backbone treatment options of DBA. Anomalies in bone marrow function in DBA cases are broadly associated with both congenital and acquired bone marrow failure syndromes in human. In this review different literatures were searched in Medline (eg. PubMed, PMC, Hinari, Google scholar), OMIM, EMBASE by using search engines (Google, Yahoo, Baidu Ask.com) and searching was performed by using search key words (DBA, ribosomopathies, Bone Marrow Failure Syndromes, pure red cell aplasia). Only human studies were included. This review is summarizing the current understandings of DBA.

Keywords: Diamond Blackfan Anemia; bone marrow failure syndromes; pure red cell aplasia; ribosomal proteins; ribosomopathies

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