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Open Forum Infect Dis. 2018 Dec 26;6(3):ofy354. doi: 10.1093/ofid/ofy354. eCollection 2019 Mar.

Probable Donor-Derived Human Adenovirus Type 34 Infection in 2 Kidney Transplant Recipients From the Same Donor.

Open forum infectious diseases

Matthew A Pettengill, Tara M Babu, Paritosh Prasad, Sally Chuang, Michael G Drage, Marilyn Menegus, Daryl M Lamson, Xiaoyan Lu, Dean Erdman, Nicole Pecora

Affiliations

  1. University of Rochester Medical Center, Rochester, New York.
  2. Thomas Jefferson University, Philadelphia, Pennsylvania.
  3. Wadsworth Center, New York State Department of Health, Albany, New York.
  4. US Centers for Disease Control and Prevention, Atlanta, Georgia.

PMID: 30882008 PMCID: PMC6411205 DOI: 10.1093/ofid/ofy354

Abstract

Human adenovirus type 34 (HAdV-34) infection is a recognized cause of transplant-associated hemorrhagic cystitis and, in rare cases, tubulointerstitial nephritis. The source of such infections is often difficult to assess, that is, whether acquired as a primary infection, exposure to a pathogen in the transplanted organ, or reactivation of an endogenous latent infection. We present here 2 cases of likely transplant-acquired HAdV-34 infection from the same organ donor, manifesting as tubulointerstitial nephritis in 1.

Keywords: HAdV-34; adenovirus; kidney transplant; tubulointerstitial nephritis

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