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Elkouris M, Kouroupi G, Vourvoukelis A, et al. Long Non-coding RNAs Associated With Neurodegeneration-Linked Genes Are Reduced in Parkinson's Disease Patients. Front Cell Neurosci. 2019;13:58doi: 10.3389/fncel.2019.00058.
Elkouris, M., Kouroupi, G., Vourvoukelis, A., Papagiannakis, N., Kaltezioti, V., Matsas, R., Stefanis, L., Xilouri, M., & Politis, P. K. (2019). Long Non-coding RNAs Associated With Neurodegeneration-Linked Genes Are Reduced in Parkinson's Disease Patients. Frontiers in cellular neuroscience, 1358. https://doi.org/10.3389/fncel.2019.00058
Elkouris, Maximilianos, et al. "Long Non-coding RNAs Associated With Neurodegeneration-Linked Genes Are Reduced in Parkinson's Disease Patients." Frontiers in cellular neuroscience vol. 13 (2019): 58. doi: https://doi.org/10.3389/fncel.2019.00058
Elkouris M, Kouroupi G, Vourvoukelis A, Papagiannakis N, Kaltezioti V, Matsas R, Stefanis L, Xilouri M, Politis PK. Long Non-coding RNAs Associated With Neurodegeneration-Linked Genes Are Reduced in Parkinson's Disease Patients. Front Cell Neurosci. 2019 Feb 22;13:58. doi: 10.3389/fncel.2019.00058. eCollection 2019. PMID: 30853899; PMCID: PMC6396023.
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Front Cell Neurosci. 2019 Feb 22;13:58. doi: 10.3389/fncel.2019.00058. eCollection 2019.

Long Non-coding RNAs Associated With Neurodegeneration-Linked Genes Are Reduced in Parkinson's Disease Patients.

Frontiers in cellular neuroscience

Maximilianos Elkouris, Georgia Kouroupi, Alexios Vourvoukelis, Nikolaos Papagiannakis, Valeria Kaltezioti, Rebecca Matsas, Leonidas Stefanis, Maria Xilouri, Panagiotis K Politis

Affiliations

  1. Center for Basic Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
  2. Laboratory of Cellular and Molecular Neurobiology, Hellenic Pasteur Institute Athens, Greece.
  3. Center of Clinical Research, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
  4. First Department of Neurology, National and Kapodistrian University of Athens Medical School, Athens, Greece.

PMID: 30853899 PMCID: PMC6396023 DOI: 10.3389/fncel.2019.00058

Abstract

Transcriptome analysis has identified a plethora of long non-coding RNAs (lncRNAs) expressed in the human brain and associated with neurological diseases. However, whether lncRNAs expression levels correlate with Parkinson's disease (PD) pathogenesis remains unknown. Herein, we show that a number of lncRNA genes encompassing transcriptional units in close proximity to PD-linked protein-coding genes, including

Keywords: LRRK2; Parkinson’s disease; Substantia Nigra; alpha-synuclein; exosomes; long-non coding RNAs

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