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Alatortseva GI, Lukhverchik LN, Dotsenko VV, et al. [The analysis of sero-prevalence of virus of hepatitis E among patients with HIV-infection and syphilis.]. Klin Lab Diagn. 2017;62(12):764-768doi: 10.18821/0869-2084-2017-62-12-764-768.
Alatortseva, G. I., Lukhverchik, L. N., Dotsenko, V. V., Nosik, M. N., Nesterenko, L. N., Kazyonnova, E. V., Bobkova, M. R., Sobkin, A. L., Rymanova, I. V., Sevostyanikhin, S. E., & Zverev, V. V. (2017). [The analysis of sero-prevalence of virus of hepatitis E among patients with HIV-infection and syphilis.]. Klinicheskaia laboratornaia diagnostika, 62(12), 764-768. https://doi.org/10.18821/0869-2084-2017-62-12-764-768
Alatortseva, G I, et al. "[The analysis of sero-prevalence of virus of hepatitis E among patients with HIV-infection and syphilis.]." Klinicheskaia laboratornaia diagnostika vol. 62,12 (2017): 764-768. doi: https://doi.org/10.18821/0869-2084-2017-62-12-764-768
Alatortseva GI, Lukhverchik LN, Dotsenko VV, Nosik MN, Nesterenko LN, Kazyonnova EV, Bobkova MR, Sobkin AL, Rymanova IV, Sevostyanikhin SE, Zverev VV. [The analysis of sero-prevalence of virus of hepatitis E among patients with HIV-infection and syphilis.]. Klin Lab Diagn. 2017;62(12):764-768. doi: 10.18821/0869-2084-2017-62-12-764-768. Russian. PMID: 30856311.
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Klin Lab Diagn. 2017;62(12):764-768. doi: 10.18821/0869-2084-2017-62-12-764-768.

[The analysis of sero-prevalence of virus of hepatitis E among patients with HIV-infection and syphilis.].

Klinicheskaia laboratornaia diagnostika

[Article in Russian]
G I Alatortseva, L N Lukhverchik, V V Dotsenko, M N Nosik, L N Nesterenko, E V Kazyonnova, M R Bobkova, A L Sobkin, I V Rymanova, S E Sevostyanikhin, V V Zverev

Affiliations

  1. The Federal state budget scientific institution "The I.I. Mechnikov research institute of vaccines and serums", 105064, Moscow, Russia.
  2. The D.I. Ivanovsky institute of virology of The Federal state budget scientific institution "The N.F. Gamaleia Federal research center of epidemiology and microbiology" of Minzdrav of Russia, 123098, Moscow, Russia.
  3. The state budget institution of health care "The G.A. Zahar`in tuberculosis clinical hospital ?3" of the Moscow health care department, 125466, Moscow, Russia.

PMID: 30856311 DOI: 10.18821/0869-2084-2017-62-12-764-768

Abstract

The infection with hepatitis E virus is one of causes of liver diseases in patients with secondary immunodeficiency, including HIVinfected ones. The study was carried out concerning analysis of rate of detection of serological markers of infection with hepatitis E virus in samples of blood serums of HIV-infected patients and other group of patients with expressed immuno-suppression - patients with syphilis. The sero-prevalence of hepatitis E virus on IgM-antibodies among HIV-infected patients in Moscow made up to 21.7% and 2.9% correspondingly. In the examined group from the Far-East region the highest sero-prevalence of hepatitis E virus on specific IgE-antibodies (73%) is established in the group of patients infected with HIV subtype B. The most frequently IgG and IgM antibodies to hepatitis E virus were detected in HIV-infected patients at the stage of disease 4B. The examined group of patients with syphilis the sero-prevalence of hepatitis E virus made up to 14.7% that significantly surpasses the given indicator in the group of healthy persons (1.7%). The increasing of the level of sero-postivity is demonstrated in the groups of patients with latent syphilis and on the second stage of disease. Therefore, the highest values of sero-prevalence of hepatitis E virus is observed in the groups of HIV-infected patients and patients with syphilis at late stages of disease. In the Russian Federation, the identification of antibodies to hepatitis E virus in HIV-infected patients depends of the region of residence.

Keywords: HIV-infection; IgG-antibodies to hepatitis E virus; hepatitis E virus; igM-antibodies to hepatitis E virus; sero-prevalence; syphilis

Conflict of interest statement

The authors declare no conflict of interest.

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