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Neugebauer P, Cardona J, Besenhard MO, et al. Crystal Shape Modification via Cycles of Growth and Dissolution in a Tubular Crystallizer. Cryst Growth Des. 2018;18(8):4403-4415doi: 10.1021/acs.cgd.8b00371.
Neugebauer, P., Cardona, J., Besenhard, M. O., Peter, A., Gruber-Woelfler, H., Tachtatzis, C., Cleary, A., Andonovic, I., Sefcik, J., & Khinast, J. G. (2018). Crystal Shape Modification via Cycles of Growth and Dissolution in a Tubular Crystallizer. Crystal growth & design, 18(8), 4403-4415. https://doi.org/10.1021/acs.cgd.8b00371
Neugebauer, Peter, et al. "Crystal Shape Modification via Cycles of Growth and Dissolution in a Tubular Crystallizer." Crystal growth & design vol. 18,8 (2018): 4403-4415. doi: https://doi.org/10.1021/acs.cgd.8b00371
Neugebauer P, Cardona J, Besenhard MO, Peter A, Gruber-Woelfler H, Tachtatzis C, Cleary A, Andonovic I, Sefcik J, Khinast JG. Crystal Shape Modification via Cycles of Growth and Dissolution in a Tubular Crystallizer. Cryst Growth Des. 2018 Aug 01;18(8):4403-4415. doi: 10.1021/acs.cgd.8b00371. Epub 2018 Jun 15. PMID: 30918477; PMCID: PMC6430499.
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Cryst Growth Des. 2018 Aug 01;18(8):4403-4415. doi: 10.1021/acs.cgd.8b00371. Epub 2018 Jun 15.

Crystal Shape Modification via Cycles of Growth and Dissolution in a Tubular Crystallizer.

Crystal growth & design

Peter Neugebauer, Javier Cardona, Maximilian O Besenhard, Anna Peter, Heidrun Gruber-Woelfler, Christos Tachtatzis, Alison Cleary, Ivan Andonovic, Jan Sefcik, Johannes G Khinast

Affiliations

  1. Graz University of Technology, Institute of Process and Particle Engineering, Inffeldgasse 13, 8010 Graz, Austria.
  2. Centre for Intelligent Dynamic Communications, Department of Electronic and Electrical Engineering, University of Strathclyde, Royal College Building, 204 George Street, Glasgow, G1 1XW, U.K.
  3. Department of Chemical Engineering, University College London, Torrington Place, London, WC1E 7JE, U.K.
  4. Research Center for Pharmaceutical Engineering (RCPE) GmbH, Inffeldgasse 13, 8010 Graz, Austria.
  5. Department of Chemical and Process Engineering, University of Strathclyde, 75 Montrose Street, Glasgow, G1 1XJ, U.K.

PMID: 30918477 PMCID: PMC6430499 DOI: 10.1021/acs.cgd.8b00371

Abstract

Besides size and polymorphic form, crystal shape takes a central role in engineering advanced solid materials for the pharmaceutical and chemical industries. This work demonstrates how multiple cycles of growth and dissolution can manipulate the habit of an acetylsalicylic acid crystal population. Considerable changes of the crystal habit could be achieved within minutes due to rapid cycling, i.e., up to 25 cycles within <10 min. The required fast heating and cooling rates were facilitated using a tubular reactor design allowing for superior temperature control. The face-specific interactions between solvent and the crystals' surface result in face-specific growth and dissolution rates and hence alterations of the final shape of the crystals in solution. Accurate quantification of the crystal shapes was essential for this work, but is everything except simple. A commercial size and shape analyzer had to be adapted to achieve the required accuracy. Online size, and most important shape, analysis was achieved using an automated microscope equipped with a flow-through cell, in combination with a dedicated image analysis routine for particle tracking and shape analysis. Due to the implementation of this analyzer, capable of obtaining statistics on the crystals' shape while still in solution (no sampling and manipulation required), the dynamic behavior of the size shape distribution could be studied. This enabled a detailed analysis of the solvent's effect on the change in crystal habit.

Conflict of interest statement

The authors declare no competing financial interest.

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