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Ohata S, Hara K, Arai T, et al. A case of pulmonary tuberculosis diagnosed in a patient with manifestations of haemophagocytic lymphohistiocytosis. Oxf Med Case Reports. 2019;2019(3):omz013doi: 10.1093/omcr/omz013.
Ohata, S., Hara, K., Arai, T., Takayoshi, T., Nishiyama, K., Yasutomo, Y., Yokono, K., & Sugimoto, T. (2019). A case of pulmonary tuberculosis diagnosed in a patient with manifestations of haemophagocytic lymphohistiocytosis. Oxford medical case reports, 2019(3), omz013. https://doi.org/10.1093/omcr/omz013
Ohata, Shinya, et al. "A case of pulmonary tuberculosis diagnosed in a patient with manifestations of haemophagocytic lymphohistiocytosis." Oxford medical case reports vol. 2019,3 (2019): omz013. doi: https://doi.org/10.1093/omcr/omz013
Ohata S, Hara K, Arai T, Takayoshi T, Nishiyama K, Yasutomo Y, Yokono K, Sugimoto T. A case of pulmonary tuberculosis diagnosed in a patient with manifestations of haemophagocytic lymphohistiocytosis. Oxf Med Case Reports. 2019 Mar 29;2019(3):omz013. doi: 10.1093/omcr/omz013. eCollection 2019 Mar. PMID: 30949351; PMCID: PMC6440261.
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Oxf Med Case Reports. 2019 Mar 29;2019(3):omz013. doi: 10.1093/omcr/omz013. eCollection 2019 Mar.

A case of pulmonary tuberculosis diagnosed in a patient with manifestations of haemophagocytic lymphohistiocytosis.

Oxford medical case reports

Shinya Ohata, Kenta Hara, Takashi Arai, Tomofumi Takayoshi, Katsuhito Nishiyama, Yoshiro Yasutomo, Koichi Yokono, Takeshi Sugimoto

Affiliations

  1. Department of Hematology and Oncology, Kita-Harima Medical Center, Hyogo, Japan.
  2. Department of Diabetes and Endocrinology, Kita-Harima Medical Center, Hyogo, Japan.
  3. Department of General and Geriatric Internal Medicine, Kita-Harima Medical Center, Hyogo, Japan.

PMID: 30949351 PMCID: PMC6440261 DOI: 10.1093/omcr/omz013

Abstract

An 80-year-old woman was admitted with continuous fever, hepatic dysfunction and cytopaenia. The presence of hepatosplenomegaly, hyperferritinaemia, hypofibrinogenaemia and phagocytosis by macrophages in the bone marrow was consistent with a diagnosis of haemophagocytic lymphohistiocytosis (HLH). We suspected that HLH was induced by pre-existing tuberculosis, and antitubercular agents were started. Positive nucleic acid amplification and sputum culture for

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