Display options
Cite
Mansour-Ghanaei F, Pourmasoumi M, Hadi A, et al. Efficacy of curcumin/turmeric on liver enzymes in patients with non-alcoholic fatty liver disease: A systematic review of randomized controlled trials. Integr Med Res. 2018;8(1):57-61doi: 10.1016/j.imr.2018.07.004.
Mansour-Ghanaei, F., Pourmasoumi, M., Hadi, A., & Joukar, F. (2019). Efficacy of curcumin/turmeric on liver enzymes in patients with non-alcoholic fatty liver disease: A systematic review of randomized controlled trials. Integrative medicine research, 8(1), 57-61. https://doi.org/10.1016/j.imr.2018.07.004
Mansour-Ghanaei, Fariborz, et al. "Efficacy of curcumin/turmeric on liver enzymes in patients with non-alcoholic fatty liver disease: A systematic review of randomized controlled trials." Integrative medicine research vol. 8,1 (2019): 57-61. doi: https://doi.org/10.1016/j.imr.2018.07.004
Mansour-Ghanaei F, Pourmasoumi M, Hadi A, Joukar F. Efficacy of curcumin/turmeric on liver enzymes in patients with non-alcoholic fatty liver disease: A systematic review of randomized controlled trials. Integr Med Res. 2019 Mar;8(1):57-61. doi: 10.1016/j.imr.2018.07.004. Epub 2018 Jul 27. PMID: 30949432; PMCID: PMC6428926.
Copy Download .nbib Format: NLM
Share it on

Integr Med Res. 2019 Mar;8(1):57-61. doi: 10.1016/j.imr.2018.07.004. Epub 2018 Jul 27.

Efficacy of curcumin/turmeric on liver enzymes in patients with non-alcoholic fatty liver disease: A systematic review of randomized controlled trials.

Integrative medicine research

Fariborz Mansour-Ghanaei, Makan Pourmasoumi, Amir Hadi, Farahnaz Joukar

Affiliations

  1. Gastrointestinal & Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences (GUMS), Rasht, Iran.
  2. Caspian Digestive Diseases Research Center, Guilan University of Medical Sciences (GUMS), Rasht, Iran.

PMID: 30949432 PMCID: PMC6428926 DOI: 10.1016/j.imr.2018.07.004

Abstract

BACKGROUND: Several studies reported that curcumin supplementation could improve non-alcoholic fatty liver disease (NAFLD). The aim of this study was to evaluate the efficacy of curcumin/turmeric supplementation on liver enzymes in patients with NAFLD.

METHODS: PubMed, Scopus, Web of Science and Google Scholar were systematically searched until December 2017. We included randomized controlled trials (RCTs) which examined effect of curcumin/turmeric supplementation on NAFLD in adult participants. Main outcome was alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Potential risks of bias (ROB) were assessed by using Cochrane ROB tool.

RESULTS: All included studies showed low ROB in most of item of Cochrane ROB tool. Meta-analysis of 4 randomized controlled trials including 228 subjects showed a trend toward significant reduction of ALT blood concentrations in subgroup with ≥1000 mg/day curcumin supplementation (-11.36 IU/L, 95% CI: -22.75 to 0.02;

CONCLUSION: This review suggests that curcumin/turmeric might have a favorable effect on NAFLD in higher dosage. Further high-quality studies with large-scale and higher dosage are warranted.

Keywords: Alanine transaminase; Aspartate aminotransferases; Curcumin; Meta-analysis; Non-alcoholic fatty liver

References

  1. Free Radic Biol Med. 2000 Apr 15;28(8):1303-12 - PubMed
  2. Cancer Res. 2002 Jul 1;62(13):3868-75 - PubMed
  3. Pharmacol Toxicol. 2003 Jan;92(1):33-8 - PubMed
  4. Hepatology. 2006 Feb;43(2 Suppl 1):S99-S112 - PubMed
  5. Drug Metab Dispos. 2007 Jan;35(1):110-5 - PubMed
  6. Phytomedicine. 2008 Apr;15(4):306-9 - PubMed
  7. Diabetes Res Clin Pract. 2008 May;80(2):185-91 - PubMed
  8. J Clin Epidemiol. 2009 Oct;62(10):1006-12 - PubMed
  9. Curr Drug Targets. 2011 Mar 1;12(3):332-47 - PubMed
  10. Ulus Travma Acil Cerrahi Derg. 2011 Jan;17(1):14-8 - PubMed
  11. Curr Pharm Biotechnol. 2012 Jan;13(1):218-28 - PubMed
  12. Diabetes Care. 2011 May;34(5):1139-44 - PubMed
  13. Drug Metab Pharmacokinet. 2012;27(2):242-7 - PubMed
  14. J Pharm Pharmacol. 2012 Mar;64(3):404-12 - PubMed
  15. Br J Pharmacol. 2012 Aug;166(8):2212-27 - PubMed
  16. Curr Pharm Des. 2013;19(11):2032-46 - PubMed
  17. Curr Pharm Des. 2013;19(11):2101-13 - PubMed
  18. Biofactors. 2013 Jan-Feb;39(1):88-100 - PubMed
  19. Redox Biol. 2013 Sep 17;1:448-56 - PubMed
  20. Clin Nutr. 2014 Apr;33(2):186-90 - PubMed
  21. BMC Complement Altern Med. 2014 Feb 11;14:53 - PubMed
  22. World J Gastroenterol. 2014 Feb 21;20(7):1712-23 - PubMed
  23. Chin J Nat Med. 2014 May;12(5):335-44 - PubMed
  24. World J Gastroenterol. 2014 Jun 21;20(23):7339-46 - PubMed
  25. World J Gastroenterol. 2014 Jul 28;20(28):9338-44 - PubMed
  26. Molecules. 2014 Dec 01;19(12):20091-112 - PubMed
  27. J Evid Based Complementary Altern Med. 2015 Jul;20(3):228-38 - PubMed
  28. Acta Virol. 2015 Sep;59(3):221-7 - PubMed
  29. Liver Int. 2016 Jan;36(1):5-20 - PubMed
  30. Cell Immunol. 2015 Nov-Dec;298(1-2):88-95 - PubMed
  31. Hepatology. 2016 Jul;64(1):73-84 - PubMed
  32. Phytother Res. 2016 Sep;30(9):1540-8 - PubMed
  33. Int J Food Sci Nutr. 2016 Dec;67(8):1024-9 - PubMed
  34. PLoS One. 2016 Aug 25;11(8):e0161792 - PubMed
  35. J BUON. 2016 Sept-Oct;21(5):1050-1060 - PubMed
  36. Int Immunopharmacol. 2017 Mar;44:174-182 - PubMed
  37. Drug Res (Stuttg). 2017 Apr;67(4):244-251 - PubMed
  38. PLoS One. 2017 Mar 3;12(3):e0172900 - PubMed
  39. J Am Coll Nutr. 2017 May-Jun;36(4):261-267 - PubMed
  40. World J Gastroenterol. 2017 Jun 21;23(23):4146-4157 - PubMed
  41. Control Clin Trials. 1986 Sep;7(3):177-88 - PubMed
  42. Planta Med. 1983 Nov;49(3):185-7 - PubMed

Publication Types