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Mrozikiewicz-Rakowska B, Nehring P, Szymański K, et al. Selected RANKL/RANK/OPG system genetic variants in diabetic foot patients. J Diabetes Metab Disord. 2018;17(2):287-296doi: 10.1007/s40200-018-0372-4.
Mrozikiewicz-Rakowska, B., Nehring, P., Szymański, K., Sobczyk-Kopcioł, A., Płoski, R., Drygas, W., Krzymień, J., Acharya, N. A., Czupryniak, L., & Przybyłkowski, A. (2018). Selected RANKL/RANK/OPG system genetic variants in diabetic foot patients. Journal of diabetes and metabolic disorders, 17(2), 287-296. https://doi.org/10.1007/s40200-018-0372-4
Mrozikiewicz-Rakowska, Beata, et al. "Selected RANKL/RANK/OPG system genetic variants in diabetic foot patients." Journal of diabetes and metabolic disorders vol. 17,2 (2018): 287-296. doi: https://doi.org/10.1007/s40200-018-0372-4
Mrozikiewicz-Rakowska B, Nehring P, Szymański K, Sobczyk-Kopcioł A, Płoski R, Drygas W, Krzymień J, Acharya NA, Czupryniak L, Przybyłkowski A. Selected RANKL/RANK/OPG system genetic variants in diabetic foot patients. J Diabetes Metab Disord. 2018 Nov 09;17(2):287-296. doi: 10.1007/s40200-018-0372-4. eCollection 2018 Dec. PMID: 30918864; PMCID: PMC6405386.
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J Diabetes Metab Disord. 2018 Nov 09;17(2):287-296. doi: 10.1007/s40200-018-0372-4. eCollection 2018 Dec.

Selected RANKL/RANK/OPG system genetic variants in diabetic foot patients.

Journal of diabetes and metabolic disorders

Beata Mrozikiewicz-Rakowska, Piotr Nehring, Konrad Szymański, Agnieszka Sobczyk-Kopcioł, Rafał Płoski, Wojciech Drygas, Janusz Krzymień, Nikita Amit Acharya, Leszek Czupryniak, Adam Przybyłkowski

Affiliations

  1. 1Department of Diabetology and Internal Diseases, Medical University of Warsaw, Warsaw, Poland.
  2. 2Department of Gastroenterology and Internal Medicine, Medical University of Warsaw, Banacha 1a, Warsaw, 02-097 Poland.
  3. 3Department of Medical Genetics, Medical University of Warsaw, Warsaw, Poland.
  4. 4Department of General Biology and Parasitology, Medical University of Warsaw, Warsaw, Poland.
  5. 5Department of Epidemiology, Cardiovascular Disease Prevention and Health Promotion, Institute of Cardiology, Warsaw, Poland.
  6. 6Second Faculty of Medicine, Medical University of Warsaw, Warsaw, Poland.

PMID: 30918864 PMCID: PMC6405386 DOI: 10.1007/s40200-018-0372-4

Abstract

PURPOSE: Diabetic foot is a complication of long-lasting diabetes mellitus affecting up to 15% of patients, both in type 1 and type 2 diabetes. Osteoprotegerin is involved in osteogenesis and calcification. The aim of the study was to assess the role of selected osteoprotegerin gene variants in diabetes patients with diabetic foot.

METHODS: The study involved 300 patients with diabetes and diabetic foot and 968 healthy controls. The study group was formed by 243 patients with diabetic foot of neuropathic origin, 102 with diabetic foot of neuroischemic origin and 77 with Charcot neuroarthropathy.

RESULTS: Compared to controls, rs1872426 and rs1485286 showed correlation with diabetic foot in diabetes subjects. Significant associations between rs2073618, rs1872426, rs7464496 and rs1485286 in men were reported. The aforementioned correlations were also present in type 2 diabetes patient subgroup. Variant rs1485286 was associated to diabetic foot of neuropathic origin. Sex-specificity for females was present for rs6993813 in patients with diabetic foot of neuropathic origin and type 1 diabetes. Variants rs1872426, rs2073617 and rs1485286 were correlated with CN. We found that age, body weight, body mass index, waist circumference, hip circumference and waist-hip ratio were among the basic risk factors of diabetic foot.

CONCLUSIONS: The following variants

Keywords: Diabetes; Genetic; Osteoprotegerin; Polymorphism

Conflict of interest statement

Compliance with ethical standardsThe authors declare that they have no conflict of interest.

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