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Int J Organ Transplant Med. 2018;9(2):68-74. Epub 2018 May 01.

Association between .

International journal of organ transplantation medicine

S H Nabavizadeh, S Janfeshan, M H Karimi, A Eidi, R Yaghobi, A Afshari, B Geramizadeh, S A Malek-Hosseini, F Kafilzadeh

Affiliations

  1. Department of Pediatrics, Yasuj University of Medical Sciences, Yasuj, Iran.
  2. Department of Biology, Faculty of Basic Science, Science and Research Branch, Islamic Azad University, Tehran, Iran.
  3. Shiraz Transplant Research Center-Shiraz University of Medical Sciences-Shiraz- Iran.
  4. Department of Microbiology, Islamic Azad University, Jahrom, Iran.

PMID: 30834090 PMCID: PMC6390982

Abstract

BACKGROUND: Liver function indices and anti-viral immune regulatory markers can both improve graft outcomes, which lead to better post-transplantation management and increase the possibility of surveillance in liver transplant recipients with chronic hepatitis B virus (HBV) infection.

OBJECTIVE: To determine the association between the interferon regulatory factor 1 (IRF1) mRNA levels and liver enzymes in HBV-infected liver transplant recipients with and without experience of rejection.

METHODS: A total of 46 chronic HBV-infected patients who had undergone liver transplant surgery was divided into 2 groups of recipients "with rejection" and "without rejection.". Blood samples were collected form each patient on days 1, 4, and 7 post-transplantation. A SYBER GREEN real-time PCR was used to evaluate the expression level of

RESULTS: The expression of

CONCLUSION: The

Keywords: Hepatitis B virus; IRF1; Liver enzyme; Liver transplantation

Conflict of interest statement

None declared.

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