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Ari A, Atias Y, Amir J. Long-Term Follow-Up of Infants After a Brief Resolved Unexplained Event-Related Hospitalization. Pediatr Emerg Care. 2019;35(11):765-768doi: 10.1097/PEC.0000000000001816.
Ari, A., Atias, Y., & Amir, J. (2019). Long-Term Follow-Up of Infants After a Brief Resolved Unexplained Event-Related Hospitalization. Pediatric emergency care, 35(11), 765-768. https://doi.org/10.1097/PEC.0000000000001816
Ari, Anne, et al. "Long-Term Follow-Up of Infants After a Brief Resolved Unexplained Event-Related Hospitalization." Pediatric emergency care vol. 35,11 (2019): 765-768. doi: https://doi.org/10.1097/PEC.0000000000001816
Ari A, Atias Y, Amir J. Long-Term Follow-Up of Infants After a Brief Resolved Unexplained Event-Related Hospitalization. Pediatr Emerg Care. 2019 Nov;35(11):765-768. doi: 10.1097/PEC.0000000000001816. PMID: 30951030.
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Pediatr Emerg Care. 2019 Nov;35(11):765-768. doi: 10.1097/PEC.0000000000001816.

Long-Term Follow-Up of Infants After a Brief Resolved Unexplained Event-Related Hospitalization.

Pediatric emergency care

Anne Ari, Yifat Atias, Jacob Amir

Affiliations

  1. From the Departments of Pediatrics C, Schneider Children's Medical Center of Israel.
  2. Pediatric Ambulatory Center of Petach Tikva, Petach Tikva.
  3. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

PMID: 30951030 DOI: 10.1097/PEC.0000000000001816

Abstract

OBJECTIVE: A brief resolved unexplained event (BRUE) in infancy is a common reason for visiting the emergency department. However, little is known about the long-term outcomes of such an event. This study evaluates future mortality, morbidity, and/or developmental outcome after a BRUE.

METHODS: A single-center retrospective study performed in 2009 to 2013 included 87 hospitalized infants (<1 year old) fitting the American Academy of Pediatrics' criteria of a lower-risk BRUE, with 2 exceptions: no time limit to duration of episode and no age limit of ≥60 days. Hospitalized infants were followed up for up to 5 years via a telephone questionnaire to assess mortality rates, developmental delay, neurological/cardiovascular morbidity, and future hospitalizations.

RESULTS: Most infants (94%) who experienced a BRUE were hospitalized before 6 months of age. No cases of mortality occurred. In terms of developmental outcome, 1 child (1.15%) was diagnosed as having a global developmental delay and 12 (13.7%) with a language delay, similar to prevalence rates by age in the United States. Three children (3.4%) were diagnosed as having an autism spectrum disorder, with higher prevalence rates than the global average. Simple febrile and nonfebrile seizures were seen at a rate similar to the general population. None of the children developed cardiovascular disease. Rehospitalization occurred in 22% of cases: 90% for common acute pediatric causes and 10% for recurrent choking events secondary to gastroesophageal reflux disease.

CONCLUSIONS: Low-risk hospitalized infants younger than 1 year who experienced a BRUE seem to generally have an excellent prognosis.

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