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Bratton H, Alomari M, Al Momani LA, et al. Prolonged Jaundice Secondary to Amiodarone Use: A Case Report and Literature Review. Cureus. 2019;11(1):e3850doi: 10.7759/cureus.3850.
Bratton, H., Alomari, M., Al Momani, L. A., Aasen, T., Young, M., & Nie, Y. (2019). Prolonged Jaundice Secondary to Amiodarone Use: A Case Report and Literature Review. Cureus, 11(1), e3850. https://doi.org/10.7759/cureus.3850
Bratton, Hunter, et al. "Prolonged Jaundice Secondary to Amiodarone Use: A Case Report and Literature Review." Cureus vol. 11,1 (2019): e3850. doi: https://doi.org/10.7759/cureus.3850
Bratton H, Alomari M, Al Momani LA, Aasen T, Young M, Nie Y. Prolonged Jaundice Secondary to Amiodarone Use: A Case Report and Literature Review. Cureus. 2019 Jan 08;11(1):e3850. doi: 10.7759/cureus.3850. PMID: 30891390; PMCID: PMC6411331.
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Cureus. 2019 Jan 08;11(1):e3850. doi: 10.7759/cureus.3850.

Prolonged Jaundice Secondary to Amiodarone Use: A Case Report and Literature Review.

Cureus

Hunter Bratton, Mohammad Alomari, Laith A Al Momani, Tyler Aasen, Mark Young, Nie

Affiliations

  1. Internal Medicine, East Tennessee State University, Johnson City, USA.
  2. Internal Medicine, Fairview Hospital, Cleveland, USA.

PMID: 30891390 PMCID: PMC6411331 DOI: 10.7759/cureus.3850

Abstract

Adverse reactions to the antiarrhythmic medication amiodarone are severe, potentially life-threatening, and not rare. One in three patients on long-term therapy experience elevated liver enzymes, and clinically apparent liver toxicity occurs in 1% of patients treated. We report the case of a 76-year-old patient with amiodarone-induced intrahepatic cholestasis and prolonged hyperbilirubinemia despite the discontinuation of the offending agent. Current research hypothesizes that amiodarone leads to hepatic injury both by direct hepatotoxicity and by increasing the likelihood of hepatocytes to create abnormal, toxic metabolites. Increased awareness of such an adverse effect can guide clinicians toward the possible underlying etiologies of prolonged jaundice.

Keywords: adverse effects; amiodarone; hyperbilirubinemia; intrahepatic cholestasis; prolonged jaundice

Conflict of interest statement

The authors have declared that no competing interests exist.

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