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Infect Dis Clin Pract (Baltim Md). 2018 Nov;26(6):e80-e84. doi: 10.1097/IPC.0000000000000654.

Zika Virus-Associated Guillain-Barré Syndrome in a Returning US Traveler.

Infectious diseases in clinical practice (Baltimore, Md.)

Jason Beattie, Sunita Parajuli, Matthew Sanger, Gregory Lee, Perrin Pleninger, George Crowley, Sophia Kwon, Vivek Murthy, Jeffrey A Manko, Arthur Caplan, Elizabeth Dufort, Daniel M Pastula, Anna Nolan

Affiliations

  1. Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, New York University, School of Medicine.
  2. Department of Medicine, Division of Infectious Diseases, New York University, School of Medicine.
  3. Department of Neurology, New York University, School of Medicine.
  4. Department of Emergency Medicine, New York University, School of Medicine.
  5. Division of Ethics, Department of Population Health, New York University, School of Medicine.
  6. New York State Department of Health, Division of Epidemiology, Albany, NY.
  7. Departments of Neurology, Medicine, and Epidemiology, University of Colorado Denver, Aurora, CO.
  8. Department of Environmental Medicine, New York University, School of Medicine, New York, NY.

PMID: 30923438 PMCID: PMC6433380 DOI: 10.1097/IPC.0000000000000654

Abstract

Zika virus (ZIKV) infection has been associated with Guillain-Barré Syndrome (GBS). Roughly 60% of people in countries such as the U.S. live in areas at risk for seasonal spread of ZIKV. ZIKV belongs to a class of diseases that is not typically seen in hospital settings across the U.S. and Europe. We describe the case presentation, management, and treatment of ZIKV infection complicated by GBS. A 64-year-old woman with recent travel to the Dominican Republic presented with rash followed by an acute, ascending polyneuropathy consistent with GBS. She was confirmed to have an acute ZIKV infection by detection of ZIKV nucleic acid by reverse transcription-polymerase chain reaction. She met Brighton Collaboration criteria level 1 evidence for GBS. She received two courses of intravenous immunoglobulin and slowly improved, though still had weakness at discharge. More research is needed to identify the pathophysiology behind ZIKV-associated GBS and its optimal treatment. Prevention is fundamental to limiting infection and spread of ZIKV.

Conflict of interest statement

Author Disclaimers: The authors declare that there is no conflict of interest regarding the publication of this paper.

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