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Smits LM, Reinhardt L, Reinhardt P, et al. Modeling Parkinson's disease in midbrain-like organoids. NPJ Parkinsons Dis. 2019;5:5doi: 10.1038/s41531-019-0078-4.
Smits, L. M., Reinhardt, L., Reinhardt, P., Glatza, M., Monzel, A. S., Stanslowsky, N., Rosato-Siri, M. D., Zanon, A., Antony, P. M., Bellmann, J., Nicklas, S. M., Hemmer, K., Qing, X., Berger, E., Kalmbach, N., Ehrlich, M., Bolognin, S., Hicks, A. A., Wegner, F., Sterneckert, J. L., & Schwamborn, J. C. (2019). Modeling Parkinson's disease in midbrain-like organoids. NPJ Parkinson's disease, 55. https://doi.org/10.1038/s41531-019-0078-4
Smits, Lisa M, et al. "Modeling Parkinson's disease in midbrain-like organoids." NPJ Parkinson's disease vol. 5 (2019): 5. doi: https://doi.org/10.1038/s41531-019-0078-4
Smits LM, Reinhardt L, Reinhardt P, Glatza M, Monzel AS, Stanslowsky N, Rosato-Siri MD, Zanon A, Antony PM, Bellmann J, Nicklas SM, Hemmer K, Qing X, Berger E, Kalmbach N, Ehrlich M, Bolognin S, Hicks AA, Wegner F, Sterneckert JL, Schwamborn JC. Modeling Parkinson's disease in midbrain-like organoids. NPJ Parkinsons Dis. 2019 Apr 05;5:5. doi: 10.1038/s41531-019-0078-4. eCollection 2019. PMID: 30963107; PMCID: PMC6450999.
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NPJ Parkinsons Dis. 2019 Apr 05;5:5. doi: 10.1038/s41531-019-0078-4. eCollection 2019.

Modeling Parkinson's disease in midbrain-like organoids.

NPJ Parkinson's disease

Lisa M Smits, Lydia Reinhardt, Peter Reinhardt, Michael Glatza, Anna S Monzel, Nancy Stanslowsky, Marcelo D Rosato-Siri, Alessandra Zanon, Paul M Antony, Jessica Bellmann, Sarah M Nicklas, Kathrin Hemmer, Xiaobing Qing, Emanuel Berger, Norman Kalmbach, Marc Ehrlich, Silvia Bolognin, Andrew A Hicks, Florian Wegner, Jared L Sterneckert, Jens C Schwamborn

Affiliations

  1. 1Luxembourg Centre for Systems Biomedicine (LCSB), Developmental and Cellular Biology, University of Luxembourg, Belvaux, Luxembourg.
  2. 2DFG-Center for Regenerative Therapies, Technische Universität Dresden, Dresden, Germany.
  3. 3Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Münster, Germany.
  4. 6Present Address: Neuroscience Discovery - Biology Department, AbbVie Deutschland GmbH & Co KG, Ludwigshafen, Germany.
  5. 4Department of Neurology, Hannover Medical School, Hannover, Germany.
  6. Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy.

PMID: 30963107 PMCID: PMC6450999 DOI: 10.1038/s41531-019-0078-4

Abstract

Modeling Parkinson's disease (PD) using advanced experimental in vitro models is a powerful tool to study disease mechanisms and to elucidate unexplored aspects of this neurodegenerative disorder. Here, we demonstrate that three-dimensional (3D) differentiation of expandable midbrain floor plate neural progenitor cells (mfNPCs) leads to organoids that resemble key features of the human midbrain. These organoids are composed of midbrain dopaminergic neurons (mDANs), which produce and secrete dopamine. Midbrain-specific organoids derived from PD patients carrying the

Conflict of interest statement

The authors declare no competing interests.

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