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Kaddam LA, Fdl-Elmula I, Eisawi OA, et al. Biochemical effects and safety of Gum arabic (. Blood Res. 2019;54(1):31-37doi: 10.5045/br.2019.54.1.31.
Kaddam, L. A., Fdl-Elmula, I., Eisawi, O. A., Abdelrazig, H. A., Elnimeiri, M. K., & Saeed, A. M. (2019). Biochemical effects and safety of Gum arabic (. Blood research, 54(1), 31-37. https://doi.org/10.5045/br.2019.54.1.31
Kaddam, Lamis AbdelGadir, et al. "Biochemical effects and safety of Gum arabic (." Blood research vol. 54,1 (2019): 31-37. doi: https://doi.org/10.5045/br.2019.54.1.31
Kaddam LA, Fdl-Elmula I, Eisawi OA, Abdelrazig HA, Elnimeiri MK, Saeed AM. Biochemical effects and safety of Gum arabic (. Blood Res. 2019 Mar;54(1):31-37. doi: 10.5045/br.2019.54.1.31. Epub 2019 Mar 21. PMID: 30956961; PMCID: PMC6439290.
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Blood Res. 2019 Mar;54(1):31-37. doi: 10.5045/br.2019.54.1.31. Epub 2019 Mar 21.

Biochemical effects and safety of Gum arabic (.

Blood research

Lamis AbdelGadir Kaddam, Imad Fdl-Elmula, Omer Ali Eisawi, Haydar Awad Abdelrazig, Mustafa Khidir Elnimeiri, Amal Mahmoud Saeed

Affiliations

  1. Department of Physiology, Faculty of Medicine, Al Neelain University, Khartoum, Sudan.
  2. Department of Clinical Genetics, Faculty of Medicine, Al Neelain University, Khartoum, Sudan.
  3. Department of Hematology, Military Hospital Khartoum, Khartoum, Sudan.
  4. Department of Pediatrics, Military Hospital Khartoum, Khartoum, Sudan.
  5. Department of Community Medicine, Faculty of Medicine, Al Neelain University, Khartoum, Sudan.
  6. Department of Physiology, Faculty of Medicine, University of Khartoum, Khartoum, Sudan.

PMID: 30956961 PMCID: PMC6439290 DOI: 10.5045/br.2019.54.1.31

Abstract

BACKGROUND: Sickle cell anemia (SCA) is a hereditary chronic hemolytic anemia with several clinical consequences. Intravascular sickling of red blood cells leads to multi-organ dysfunction. Moreover, several biochemical abnormalities have been associated with SCA. Gum arabic (GA) is an edible dried gummy exudate obtained from

METHODS: Forty-seven patients (5-42 yr) carrying hemoglobin SS were recruited. The patients received 30 g/day GA for 12 weeks. Blood samples were collected before administering GA and then after 4, 8, and 12 weeks. Liver enzymes, total protein, albumin, electrolytes, urea, creatinine, and uric acid were determined in the serum. The study was approved by the Al Neelain University Institutional Review Board and Research Ethics Committee Ministry of Health. The trial was registered at ClinicalTrials.gov (identifier: NCT02467257).

RESULTS: GA significantly decreased direct bilirubin level [statistical significance (

CONCLUSION: GA may alter the disease severity in SCA as demonstrated by its ability to decrease direct bilirubin and urea levels in the serum.

Keywords: Bilirubin; Gum arabic; Liver enzyme; Sickle cell anemia; Urea

Conflict of interest statement

Authors' Disclosures of Potential Conflicts of Interest: No potential conflicts of interest relevant to this article were reported.

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