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Gołyński M, Metyk M, Szkodziak P, et al. Pituitary-testicular Axis Dysfunction in Methimazole-induced Hypothyroidism in Rats. J Vet Res. 2019;63(1):161-166doi: 10.2478/jvetres-2019-0008.
Gołyński, M., Metyk, M., Szkodziak, P., Lutnicki, K., Kalisz, G., Szczepanik, M., Wilkołek, P., & Dobrowolski, P. (2019). Pituitary-testicular Axis Dysfunction in Methimazole-induced Hypothyroidism in Rats. Journal of veterinary research, 63(1), 161-166. https://doi.org/10.2478/jvetres-2019-0008
Gołyński, Marcin, et al. "Pituitary-testicular Axis Dysfunction in Methimazole-induced Hypothyroidism in Rats." Journal of veterinary research vol. 63,1 (2019): 161-166. doi: https://doi.org/10.2478/jvetres-2019-0008
Gołyński M, Metyk M, Szkodziak P, Lutnicki K, Kalisz G, Szczepanik M, Wilkołek P, Dobrowolski P. Pituitary-testicular Axis Dysfunction in Methimazole-induced Hypothyroidism in Rats. J Vet Res. 2019 Mar 22;63(1):161-166. doi: 10.2478/jvetres-2019-0008. eCollection 2019 Mar. PMID: 30989148; PMCID: PMC6458557.
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J Vet Res. 2019 Mar 22;63(1):161-166. doi: 10.2478/jvetres-2019-0008. eCollection 2019 Mar.

Pituitary-testicular Axis Dysfunction in Methimazole-induced Hypothyroidism in Rats.

Journal of veterinary research

Marcin Gołyński, Michał Metyk, Piotr Szkodziak, Krzysztof Lutnicki, Grzegorz Kalisz, Marcin Szczepanik, Piotr Wilkołek, Piotr Dobrowolski

Affiliations

  1. Department and Clinic of Animal Internal Diseases, Faculty of Veterinary Medicine, University of Life Sciences, 20-612 Lublin, Poland.
  2. 3rd Chair and Department of Gynecology, Medical University of Lublin, 20-954 Lublin, Poland.
  3. Department of Biopharmacy, Chair of Chemistry, Faculty of Pharmacy with Medical Analytics Division, Medical University of Lublin, 20-093 Lublin, Poland.
  4. Department of Comparative Anatomy and Anthropology, Maria Curie-Sk?odowska University, 20-033 Lublin, Poland.

PMID: 30989148 PMCID: PMC6458557 DOI: 10.2478/jvetres-2019-0008

Abstract

INTRODUCTION: Thyroid hormones play a major role in the regulation of testicular maturation and growth and in the control of Sertoli and Leydig cell functions in adulthood. When naturally occurring, hypothyroidism causes male hypogonadotropic hypogonadism and Sertoli cell function disorders, but when iatrogenic and methimazole-induced its influence on the pituitary-testicular axis function with respect to Sertoli cells is poorly known.

MATERIAL AND METHODS: Male adult Wistar rats (n = 14) were divided into two groups: E - taking methimazole orally for 60 days, and C - control animals. After 60 d, the concentrations in serum of testosterone, follicle-stimulating and luteinising hormones, and inhibins A and B were measured. Testicles were examined morphologically: the apoptotic Sertoli cell percentage (ASC%) and number of these cells functional per tubular mm

RESULTS: In group E, inhibin A was higher while inhibin B was lower than in group C. ASC% was higher and FSCN/Tmm

CONCLUSION: A specific modulation of Sertoli cell function in the course of methimazole-induced hypothyroidism leads to a simultaneous concentration increase in inhibin A and decrease in B. Inhibin A might share responsibility for pituitary-testicular axis dysfunction and hypogonadotropic hypogonadism in this model of hypothyroidism.

Keywords: hypogonadism; inhibins; rats; sex hormones; thionamines; thyroid gland

Conflict of interest statement

Conflict of Interest Conflict of Interests Statement: The authors declare that there is no conflict of interests regarding the publication of this article.

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