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Epigenet Insights. 2019 Apr 12;12:2516865719842534. doi: 10.1177/2516865719842534. eCollection 2019.

Succinate Dehydrogenase-Deficient Gastrointestinal Stromal Tumors: Small Steps Toward Personalized Medicine?.

Epigenetics insights

Gloria Ravegnini, Riccardo Ricci

Affiliations

  1. Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.
  2. Department of Pathology, Università Cattolica del Sacro Cuore, Rome, Italy.
  3. UOC di Anatomia Patologica, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy.

PMID: 31020269 PMCID: PMC6463228 DOI: 10.1177/2516865719842534

Abstract

Various molecular triggers define heterogeneous subsets of gastrointestinal stromal tumors (GISTs), differing in clinical behavior and drug sensitivity.

Keywords: DNA methylation; O6-methylguanine-DNA methyltransferase; alkylating agents; gastrointestinal stromal tumor; molecular diagnosis; wild-type gastrointestinal stromal tumor

Conflict of interest statement

Declaration of conflicting interests:R.R. received speaker’s honoraria from Novartis. G.R. declares no conflicts of interest.

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