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Abdulle A, Inman CK, Saleh A, et al. Metabolic dysfunction in Emirati subjects in Abu Dhabi: Relationship to levels of soluble RAGEs. J Clin Transl Endocrinol. 2019;16:100192doi: 10.1016/j.jcte.2019.100192.
Abdulle, A., Inman, C. K., Saleh, A., Noshi, M., Galani, D., Abdelwareth, L., Alsafar, H., Elfatih, A., Al Shamsi, H., Ali, R., Li, H., Ramasamy, R., Schmidt, A. M., Benbarka, M. M., & Hassan, M. H. (2019). Metabolic dysfunction in Emirati subjects in Abu Dhabi: Relationship to levels of soluble RAGEs. Journal of clinical & translational endocrinology, 16100192. https://doi.org/10.1016/j.jcte.2019.100192
Abdulle, Abdishakur, et al. "Metabolic dysfunction in Emirati subjects in Abu Dhabi: Relationship to levels of soluble RAGEs." Journal of clinical & translational endocrinology vol. 16 (2019): 100192. doi: https://doi.org/10.1016/j.jcte.2019.100192
Abdulle A, Inman CK, Saleh A, Noshi M, Galani D, Abdelwareth L, Alsafar H, Elfatih A, Al Shamsi H, Ali R, Li H, Ramasamy R, Schmidt AM, Benbarka MM, Hassan MH. Metabolic dysfunction in Emirati subjects in Abu Dhabi: Relationship to levels of soluble RAGEs. J Clin Transl Endocrinol. 2019 Apr 23;16:100192. doi: 10.1016/j.jcte.2019.100192. eCollection 2019 Jun. PMID: 31080742; PMCID: PMC6503160.
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J Clin Transl Endocrinol. 2019 Apr 23;16:100192. doi: 10.1016/j.jcte.2019.100192. eCollection 2019 Jun.

Metabolic dysfunction in Emirati subjects in Abu Dhabi: Relationship to levels of soluble RAGEs.

Journal of clinical & translational endocrinology

Abdishakur Abdulle, Claire K Inman, Abdelkarim Saleh, Mohamed Noshi, Divya Galani, Laila Abdelwareth, Habiba Alsafar, Abubaker Elfatih, Hefsa Al Shamsi, Raghib Ali, Huilin Li, Ravichandran Ramasamy, Ann Marie Schmidt, Mahmoud M Benbarka, Mohamed H Hassan

Affiliations

  1. Public Health Research Center, New York University Abu Dhabi, United Arab Emirates.
  2. Department of Medicine, Sheikh Khalifa Medical City, United Arab Emirates.
  3. Department of Pathology, Cleveland Clinic Abu Dhabi, United Arab Emirates.
  4. Center for Biotechnology, Khalifa University of Science & Technology, Abu Dhabi, United Arab Emirates.
  5. Department of Biomedical Engineering, Khalifa University of Science & Technology, Abu Dhabi, United Arab Emirates.
  6. Department of Population Health, New York University School of Medicine, NY, USA.
  7. Department of Medicine, New York University School of Medicine, NY, USA.

PMID: 31080742 PMCID: PMC6503160 DOI: 10.1016/j.jcte.2019.100192

Abstract

BACKGROUND: The United Arab Emirates is experiencing increasing rates of type 2 diabetes (T2D) and its complications. As soluble levels of the receptor for advanced glycation end products, (sRAGE), and endogenous secretory RAGE (esRAGE), the latter an alternatively spliced form of

METHODS: In a case-control study, we recruited Emirati subjects with T2D and controls from the Sheikh Khalifa Medical City in Abu Dhabi. Anthropomorphic characteristics, levels of plasma sRAGE and esRAGE, and routine chemistry variables were measured.

RESULTS: Two hundred and sixteen T2D subjects and 215 control subjects (mean age, 57.4 ± 12.1

CONCLUSION/DISCUSSION: Levels of sRAGE, but not esRAGE, were associated with T2D status in Abu Dhabi, but not after correction for eGFR. Elevated levels of plasma insulin in both control and T2D subjects suggests the presence of metabolic dysfunction, even in subjects without diabetes.

Keywords: ADAM10, a disintegrin and metalloproteinase domain-containing protein 10; AGEs, advanced glycation endproducts; ARIC, Atherosclerosis Risk in Communities; BMI, body mass index; CARDS, Collaborative Atorvastatin Diabetes Study; CV, coefficient of variation; DBP, diastolic blood pressure; ELISA, enzyme-linked immunosorbent assay; ESRD, end stage renal disease; FBG, fasting blood glucose; HDL, high density lipoprotein; HbA1c, glycosylated hemoglobin; Insulin resistance; Kidney function; LADA, latent autoimmune diabetes of the adult; LDL, low density lipoprotein; MMP, matrix metalloproteinase; RAGE, receptor for advanced glycation endproducts; Receptor for advanced glycation endproducts (RAGE); SBP, systolic blood pressure; SKMC, Sheikh Khalifa Medical City; Soluble RAGE (sRAGE); T2D, type 2 diabetes; TG, triglycerides; Type 2 diabetes; UAE, United Arab Emirates; UAEHFS, United Arab Emirates Healthy Futures Study; W/H ratio, Waist/Hip circumference ratio; eGFR, estimated glomerular filtration rate; esRAGE (endogenous secretory RAGE); esRAGE, endogenous secretory RAGE; hsCRP, high sensitivity C-reactive protein; sRAGE, soluble RAGE

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