Display options
Cite
Adhikari LJ, Elkins CT, Wakely PE. Squamous cells in effusions: A study of 24 cases. J Am Soc Cytopathol. 2013;3(1):21-28doi: 10.1016/j.jasc.2013.08.225.
Adhikari, L. J., Elkins, C. T., & Wakely, P. E. (2014). Squamous cells in effusions: A study of 24 cases. Journal of the American Society of Cytopathology, 3(1), 21-28. https://doi.org/10.1016/j.jasc.2013.08.225
Adhikari, Laura J, et al. "Squamous cells in effusions: A study of 24 cases." Journal of the American Society of Cytopathology vol. 3,1 (2014): 21-28. doi: https://doi.org/10.1016/j.jasc.2013.08.225
Adhikari LJ, Elkins CT, Wakely PE. Squamous cells in effusions: A study of 24 cases. J Am Soc Cytopathol. 2014 Jan - Feb;3(1):21-28. doi: 10.1016/j.jasc.2013.08.225. Epub 2013 Oct 21. PMID: 31051726.
Copy Download .nbib Format: NLM
Share it on

J Am Soc Cytopathol. 2014 Jan - Feb;3(1):21-28. doi: 10.1016/j.jasc.2013.08.225. Epub 2013 Oct 21.

Squamous cells in effusions: A study of 24 cases.

Journal of the American Society of Cytopathology

Laura J Adhikari, Camille T Elkins, Paul E Wakely

Affiliations

  1. Department of Pathology, Wexner Medical Center at The Ohio State University, Columbus, Ohio.
  2. Department of Pathology, Wexner Medical Center at The Ohio State University, Columbus, Ohio. Electronic address: [email protected].

PMID: 31051726 DOI: 10.1016/j.jasc.2013.08.225

Abstract

INTRODUCTION: Malignant squamous cells in serous effusions are rare. We present our experience with squamous cell carcinoma (SqCC) and benign squamous cells in effusions.

MATERIALS AND METHODS: Specimens were retrieved from our database using search codes as "squamous" within the final diagnosis under various serous effusions.

RESULTS: Twenty-nine specimens were recovered, and 5 of those were excluded. Of the 24 specimens, 3 were duplicates; therefore, only the first specimen from each was included for a final tally of 21 specimens. Specimens were from pleural fluid (n = 16, 76%), pericardial fluid (n = 2), pelvic fluid (n = 2), and peritoneal fluid (n = 1). Nineteen were SqCC (primary sites: 7 lung, 2 uterine cervix, 2 larynx, 2 anus, 2 esophagus, 1 tongue, 1 mandible, 1 skin, 1 vulva), and 2 patients had benign squamous cells only (1 from a ruptured esophageal adenocarcinoma and 1 from a nonmalignant esophageal rupture). In SqCC cases, a round-oval cell with dense cytoplasm was the predominant cell type (n = 12) followed by undifferentiated cells (n = 4), polygonal-type cells (n = 2), and fiber-type cells (n = 1). Of the SqCC specimens, 12 (63%) showed varying degrees of keratinization. Other features in SqCC cases included refractile rings (89%), keratin pearls (53%), and vacuolated cytoplasm (42%). Herxheimer spirals were absent. Two benign cases showed polygonal cell morphology only. All patients with SqCC died shortly after fluid collection (range 2-313 days; mean: 58.1 days).

CONCLUSIONS: Metastatic SqCC in serous effusions are rare, primarily arranged as single cells with rounded nuclei lacking visible nucleoli surrounded by a minimal amount of dense cytoplasm, and represent a dismal prognosis.

Copyright © 2014 American Society of Cytopathology. Published by Elsevier Inc. All rights reserved.

Keywords: Pelvic fluid; Pericardial fluid; Peritoneal fluid; Pleural fluid; Serous effusion; Squamous cell carcinoma

Publication Types