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Ullmann E, Perry SW, Licinio J, et al. From Allostatic Load to Allostatic State-An Endogenous Sympathetic Strategy to Deal With Chronic Anxiety and Stress?. Front Behav Neurosci. 2019;13:47doi: 10.3389/fnbeh.2019.00047.
Ullmann, E., Perry, S. W., Licinio, J., Wong, M. L., Dremencov, E., Zavjalov, E. L., Shevelev, O. B., Khotskin, N. V., Koncevaya, G. V., Khotshkina, A. S., Moshkin, M. P., Lapshin, M. S., Komelkova, M. V., Feklicheva, I. V., Tseilikman, O. B., Cherkasova, O. P., Bhui, K. S., Jones, E., Kirschbaum, C., Bornstein, S. R., & Tseilikman, V. (2019). From Allostatic Load to Allostatic State-An Endogenous Sympathetic Strategy to Deal With Chronic Anxiety and Stress?. Frontiers in behavioral neuroscience, 1347. https://doi.org/10.3389/fnbeh.2019.00047
Ullmann, Enrico, et al. "From Allostatic Load to Allostatic State-An Endogenous Sympathetic Strategy to Deal With Chronic Anxiety and Stress?." Frontiers in behavioral neuroscience vol. 13 (2019): 47. doi: https://doi.org/10.3389/fnbeh.2019.00047
Ullmann E, Perry SW, Licinio J, Wong ML, Dremencov E, Zavjalov EL, Shevelev OB, Khotskin NV, Koncevaya GV, Khotshkina AS, Moshkin MP, Lapshin MS, Komelkova MV, Feklicheva IV, Tseilikman OB, Cherkasova OP, Bhui KS, Jones E, Kirschbaum C, Bornstein SR, Tseilikman V. From Allostatic Load to Allostatic State-An Endogenous Sympathetic Strategy to Deal With Chronic Anxiety and Stress?. Front Behav Neurosci. 2019 Mar 21;13:47. doi: 10.3389/fnbeh.2019.00047. eCollection 2019. PMID: 30967764; PMCID: PMC6442703.
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Front Behav Neurosci. 2019 Mar 21;13:47. doi: 10.3389/fnbeh.2019.00047. eCollection 2019.

From Allostatic Load to Allostatic State-An Endogenous Sympathetic Strategy to Deal With Chronic Anxiety and Stress?.

Frontiers in behavioral neuroscience

Enrico Ullmann, Seth W Perry, Julio Licinio, Ma-Li Wong, Eliyahu Dremencov, Evgenii L Zavjalov, Oleg B Shevelev, Nikita V Khotskin, Galina V Koncevaya, Anna S Khotshkina, Mikhail P Moshkin, Maxim S Lapshin, Maria V Komelkova, Inna V Feklicheva, Olga B Tseilikman, Olga P Cherkasova, Kamaldeep S Bhui, Edgar Jones, Clemens Kirschbaum, Stefan R Bornstein, Vadim Tseilikman

Affiliations

  1. Department of Medicine, Carl Gustav Carus, Technical University of Dresden, Dresden, Germany.
  2. Department of Child and Adolescent Psychiatry, Psychotherapy, and Psychosomatics, University of Leipzig, Leipzig, Germany.
  3. School of Medical Biology, South Ural State University, Chelyabinsk, Russia.
  4. College of Medicine, SUNY Upstate Medical University, Syracuse, NY, United States.
  5. Institute of Molecular Physiology and Genetics, Centre for Biosciences, Slovak Academy of Sciences, Bratislava, Slovakia.
  6. Biomedical Research Center, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovakia.
  7. Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Science (RAS), Novosibirsk, Russia.
  8. Biophysics Laboratory, Institute of Laser Physics, Siberian Branch of the Russian Academy of Science, Novosibirsk, Russia.
  9. Centre for Psychiatry, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, United Kingdom.
  10. Institute of Psychiatry Psychology & Neuroscience, King's College London, London, United Kingdom.
  11. Department of Psychology, Biopsychology, Technical University of Dresden, Dresden, Germany.
  12. Faculty of Life Sciences & Medicine, Endocrinology and Diabetes, Kings College London, London, United Kingdom.

PMID: 30967764 PMCID: PMC6442703 DOI: 10.3389/fnbeh.2019.00047

Abstract

The concepts of allostatic load and overload, i. e., a dramatic increase in the allostatic load that predisposes to disease, have been extensively described in the literature. Here, we show that rats engaging in active offensive response (AOR) behavioral strategies to chronic predator scent stress (PSS) display less anxiety behavior and lower plasma cortisol levels vs. rats engaging in passive defensive response (PDR) behavioral strategies to chronic PSS. In the same chronic PSS paradigm, AOR rats also have higher lactate and lower glutamate levels in amygdala but not in control-region hippocampus vs. PDR rats. The implications of these findings for regulation of allostatic and stress responses, and post-traumatic stress disorder (PTSD) are discussed.

Keywords: PTSD (post-traumatic stress disorder); allostasis/homeostasis; behavior; glutamate; stress-diseases

References

  1. Physiol Behav. 1999 Jan 1-15;65(4-5):723-37 - PubMed
  2. Magn Reson Med. 1999 Apr;41(4):649-56 - PubMed
  3. Neuropsychopharmacology. 2001 Feb;24(2):97-129 - PubMed
  4. J Child Adolesc Psychopharmacol. 2003 Spring;13(1):65-73 - PubMed
  5. Physiol Rev. 1957 Apr;37(2):155-95 - PubMed
  6. CNS Spectr. 2001 Jul;6(7):555-6, 561-4 - PubMed
  7. Neurosci Biobehav Rev. 2005 Feb;29(1):3-38 - PubMed
  8. J Psychiatry Neurosci. 2005 Sep;30(5):315-8 - PubMed
  9. Biol Psychiatry. 2008 Oct 15;64(8):708-17 - PubMed
  10. J Neuroendocrinol. 2008 Oct;20(10):1115-37 - PubMed
  11. Neurobiol Learn Mem. 2008 Oct;90(3):495-503 - PubMed
  12. Int J Neuropsychopharmacol. 2010 Jul;13(6):747-57 - PubMed
  13. J Neurosci. 2010 Jun 2;30(22):7466-72 - PubMed
  14. Dialogues Clin Neurosci. 2002 Sep;4(3):231-49 - PubMed
  15. Clin Psychol Rev. 2012 Jun;32(4):301-15 - PubMed
  16. Nat Neurosci. 2013 Jan;16(1):33-41 - PubMed
  17. Eur Neuropsychopharmacol. 2014 Jan;24(1):142-7 - PubMed
  18. NMR Biomed. 2014 Apr;27(4):399-405 - PubMed
  19. Psychol Rev. 2014 Apr;121(2):225-47 - PubMed
  20. Horm Behav. 2014 Aug;66(3):561-6 - PubMed
  21. Front Neurosci. 2015 Feb 27;9:22 - PubMed
  22. Neuropsychopharmacology. 2016 Jan;41(1):3-23 - PubMed
  23. Neuron. 2016 Jun 1;90(5):1057-70 - PubMed
  24. Neurosci Lett. 2017 May 10;649:147-155 - PubMed
  25. JAMA Oncol. 2017 Jul 1;3(7):961-968 - PubMed
  26. Ther Adv Psychopharmacol. 2017 Feb;7(2):85-89 - PubMed
  27. Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):8390-8395 - PubMed
  28. Chronic Stress (Thousand Oaks). 2017 Jan-Dec;1:null - PubMed
  29. Front Neuroendocrinol. 2018 Oct;51:46-67 - PubMed
  30. Nat Rev Neurosci. 2018 Apr;19(4):235-249 - PubMed
  31. J Appl Physiol (1985). 2018 Sep 1;125(3):931-937 - PubMed
  32. Stress. 2019 Jan;22(1):27-35 - PubMed
  33. Am J Psychiatry. 1987 Oct;144(10):1317-9 - PubMed
  34. J Steroid Biochem. 1986 Nov;25(5B):717-21 - PubMed
  35. Magn Reson Med. 1993 Dec;30(6):672-9 - PubMed
  36. Behav Neurosci. 1993 Oct;107(5):860-6 - PubMed
  37. Magn Reson Med. 1993 Jun;29(6):804-11 - PubMed
  38. Neurosci Res. 1996 Nov;26(3):235-69 - PubMed
  39. Arch Intern Med. 1997 Oct 27;157(19):2259-68 - PubMed
  40. Behav Neurosci. 1998 Feb;112(1):251-4 - PubMed
  41. Endocr Rev. 1998 Apr;19(2):101-43 - PubMed
  42. Endocr Rev. 1998 Jun;19(3):269-301 - PubMed
  43. Dev Neurosci. 1998;20(4-5):348-57 - PubMed

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