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Rangseekaew P, Pathom-Aree W. Cave Actinobacteria as Producers of Bioactive Metabolites. Front Microbiol. 2019;10:387doi: 10.3389/fmicb.2019.00387.
Rangseekaew, P., & Pathom-Aree, W. (2019). Cave Actinobacteria as Producers of Bioactive Metabolites. Frontiers in microbiology, 10387. https://doi.org/10.3389/fmicb.2019.00387
Rangseekaew, Pharada, and Pathom-Aree, Wasu. "Cave Actinobacteria as Producers of Bioactive Metabolites." Frontiers in microbiology vol. 10 (2019): 387. doi: https://doi.org/10.3389/fmicb.2019.00387
Rangseekaew P, Pathom-Aree W. Cave Actinobacteria as Producers of Bioactive Metabolites. Front Microbiol. 2019 Mar 22;10:387. doi: 10.3389/fmicb.2019.00387. eCollection 2019. PMID: 30967844; PMCID: PMC6438885.
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Front Microbiol. 2019 Mar 22;10:387. doi: 10.3389/fmicb.2019.00387. eCollection 2019.

Cave Actinobacteria as Producers of Bioactive Metabolites.

Frontiers in microbiology

Pharada Rangseekaew, Wasu Pathom-Aree

Affiliations

  1. Doctor of Philosophy Program in Applied Microbiology (International Program) in Faculty of Science, Chiang Mai University, Chiang Mai, Thailand.
  2. Graduate School, Chiang Mai University, Chiang Mai, Thailand.
  3. Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai, Thailand.
  4. Center of Excellence in Bioresources for Agriculture, Industry and Medicine, Chiang Mai University, Chiang Mai, Thailand.

PMID: 30967844 PMCID: PMC6438885 DOI: 10.3389/fmicb.2019.00387

Abstract

Recently, there is an urgent need for new drugs due to the emergence of drug resistant pathogenic microorganisms and new infectious diseases. Members of phylum Actinobacteria are promising source of bioactive compounds notably antibiotics. The search for such new compounds has shifted to extreme or underexplored environments to increase the possibility of discovery. Cave ecosystems have attracted interest of the research community because of their unique characteristics and the microbiome residing inside including actinobacteria. At the time of writing, 47 species in 30 genera of actinobacteria were reported from cave and cave related habitats. Novel and promising bioactive compounds have been isolated and characterized. This mini-review focuses on the diversity of cultivable actinobacteria in cave and cave-related environments, and their bioactive metabolites from 1999 to 2018.

Keywords: actinobacteria; anticancer; antimicrobial; bioactive compounds; cave; diversity; karst; natural products

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