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Cabré JJ, Mur T, Costa B, et al. Feasibility and Effectiveness of Electrochemical Dermal Conductance Measurement for the Screening of Diabetic Neuropathy in Primary Care. Decoding Study (Dermal Electrochemical Conductance in Diabetic Neuropathy). J Clin Med. 2019;8(5)doi: 10.3390/jcm8050598.
Cabré, J. J., Mur, T., Costa, B., Barrio, F., López-Moya, C., Sagarra, R., García-Barco, M., Vizcaíno, J., Bonaventura, I., Ortiz, N., Flores-Mateo, G., Solà-Morales, O. (2019). Feasibility and Effectiveness of Electrochemical Dermal Conductance Measurement for the Screening of Diabetic Neuropathy in Primary Care. Decoding Study (Dermal Electrochemical Conductance in Diabetic Neuropathy). Journal of clinical medicine, 8(5), . https://doi.org/10.3390/jcm8050598
Cabré, Juan J, et al. "Feasibility and Effectiveness of Electrochemical Dermal Conductance Measurement for the Screening of Diabetic Neuropathy in Primary Care. Decoding Study (Dermal Electrochemical Conductance in Diabetic Neuropathy)." Journal of clinical medicine vol. 8,5 (2019). doi: https://doi.org/10.3390/jcm8050598
Cabré JJ, Mur T, Costa B, Barrio F, López-Moya C, Sagarra R, García-Barco M, Vizcaíno J, Bonaventura I, Ortiz N, Flores-Mateo G, Solà-Morales O. Feasibility and Effectiveness of Electrochemical Dermal Conductance Measurement for the Screening of Diabetic Neuropathy in Primary Care. Decoding Study (Dermal Electrochemical Conductance in Diabetic Neuropathy). J Clin Med. 2019 May 01;8(5). doi: 10.3390/jcm8050598. PMID: 31052426; PMCID: PMC6572367.
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J Clin Med. 2019 May 01;8(5). doi: 10.3390/jcm8050598.

Feasibility and Effectiveness of Electrochemical Dermal Conductance Measurement for the Screening of Diabetic Neuropathy in Primary Care. Decoding Study (Dermal Electrochemical Conductance in Diabetic Neuropathy).

Journal of clinical medicine

Juan J Cabré, Teresa Mur, Bernardo Costa, Francisco Barrio, Charo López-Moya, Ramon Sagarra, Montserrat García-Barco, Jesús Vizcaíno, Immaculada Bonaventura, Nicolau Ortiz, Gemma Flores-Mateo, Oriol Solà-Morales,

Affiliations

  1. Catalan Diabetes Prevention Research Group, IDIAP Jordi Gol., 43202 Reus, Barcelona, Spain. [email protected].
  2. Primary Care, CAP Rubí, Mutua Terrassa, 08191 Rubí, Spain. [email protected].
  3. Catalan Diabetes Prevention Research Group, IDIAP Jordi Gol., 43202 Reus, Barcelona, Spain. [email protected].
  4. Catalan Diabetes Prevention Research Group, IDIAP Jordi Gol., 43202 Reus, Barcelona, Spain. [email protected].
  5. Primary Care, CAP Rubí, Mutua Terrassa, 08191 Rubí, Spain. [email protected].
  6. Catalan Diabetes Prevention Research Group, IDIAP Jordi Gol., 43202 Reus, Barcelona, Spain. [email protected].
  7. Catalan Diabetes Prevention Research Group, IDIAP Jordi Gol., 43202 Reus, Barcelona, Spain. [email protected].
  8. Catalan Diabetes Prevention Research Group, IDIAP Jordi Gol., 43202 Reus, Barcelona, Spain. [email protected].
  9. Neurology Department, Hospital Mutua Terrassa, 08221 Terrassa, Spain. [email protected].
  10. Neurology Department, Hospital Universitari Sant Joan de Reus, 43202 Reus, Spain. [email protected].
  11. Catalan Diabetes Prevention Research Group, IDIAP Jordi Gol., 43202 Reus, Barcelona, Spain. [email protected].
  12. HITT (Health Innovation Technology Transer), 08006 Barcelona, Spain. [email protected].

PMID: 31052426 PMCID: PMC6572367 DOI: 10.3390/jcm8050598

Abstract

Diabetes mellitus (DM) is the leading cause of polyneuropathy in the Western world. Diabetic neuropathy (DNP) is the most common complication of diabetes and is of great clinical significance mainly due to the pain and the possibility of ulceration in the lower limbs. Early detection of neuropathy is essential in the medical management of this complication. Early unmyelinated C-fiber dysfunction is one of the typical findings of diabetic neuropathy and the first clinical manifestation of dysfunction indicating sudomotor eccrine gland impairment. In order to assess newly developed technology for the measurement of dermal electrochemical conductance (DEC), we analyzed the feasibility and effectiveness of DEC (quantitative expression of sudomotor reflex) as a screening test of DNP in primary health care centers. The study included 197 people (with type 2 diabetes, prediabetes and normal tolerance) who underwent all the protocol tests and electromyography (EMG). On comparing DEC with EMG as the gold standard, the area under the receiver operating characteristic (ROC) curve (AUC, area under the curve) was 0.58 in the whole sample, AUC = 0.65 in the diabetes population and AUC = 0.72 in prediabetes, being irrelevant in subjects without glucose disturbances (AUC = 0.47). Conclusions: In usual clinical practice, DEC is feasible, with moderate sensitivity but high specificity. It is also easy to use and interpret and requires little training, thereby making it a good screening test in populations with diabetes and prediabetes. It may also be useful in screening general populations at risk of neuropathy.

Keywords: dermal electrochemical conductance; diabetes mellitus; neuropathy; primary care; screening; sudomotor reflex

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