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Leardini-Tristao M, Charles AL, Lejay A, et al. Beneficial Effect of Exercise on Cognitive Function during Peripheral Arterial Disease: Potential Involvement of Myokines and Microglial Anti-Inflammatory Phenotype Enhancement. J Clin Med. 2019;8(5)doi: 10.3390/jcm8050653.
Leardini-Tristao, M., Charles, A. L., Lejay, A., Pizzimenti, M., Meyer, A., Estato, V., Tibiriçá, E., Andres, E., & Geny, B. (2019). Beneficial Effect of Exercise on Cognitive Function during Peripheral Arterial Disease: Potential Involvement of Myokines and Microglial Anti-Inflammatory Phenotype Enhancement. Journal of clinical medicine, 8(5), . https://doi.org/10.3390/jcm8050653
Leardini-Tristao, Marina, et al. "Beneficial Effect of Exercise on Cognitive Function during Peripheral Arterial Disease: Potential Involvement of Myokines and Microglial Anti-Inflammatory Phenotype Enhancement." Journal of clinical medicine vol. 8,5 (2019). doi: https://doi.org/10.3390/jcm8050653
Leardini-Tristao M, Charles AL, Lejay A, Pizzimenti M, Meyer A, Estato V, Tibiriçá E, Andres E, Geny B. Beneficial Effect of Exercise on Cognitive Function during Peripheral Arterial Disease: Potential Involvement of Myokines and Microglial Anti-Inflammatory Phenotype Enhancement. J Clin Med. 2019 May 10;8(5). doi: 10.3390/jcm8050653. PMID: 31083472; PMCID: PMC6571759.
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J Clin Med. 2019 May 10;8(5). doi: 10.3390/jcm8050653.

Beneficial Effect of Exercise on Cognitive Function during Peripheral Arterial Disease: Potential Involvement of Myokines and Microglial Anti-Inflammatory Phenotype Enhancement.

Journal of clinical medicine

Marina Leardini-Tristao, Anne-Laure Charles, Anne Lejay, Mégane Pizzimenti, Alain Meyer, Vanessa Estato, Eduardo Tibiriçá, Emmanuel Andres, Bernard Geny

Affiliations

  1. Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz, FIOCRUZ, Avenida Brasil 4365, 21040-360, Rio de Janeiro, Brazil. [email protected].
  2. Université de Strasbourg, Fédération de médecine translationnelle de Strasbourg (FMTS), Faculté de Médecine, Equipe d'accueil 3072, 11 Rue Humann, 67000 Strasbourg, France. [email protected].
  3. Université de Strasbourg, Fédération de médecine translationnelle de Strasbourg (FMTS), Faculté de Médecine, Equipe d'accueil 3072, 11 Rue Humann, 67000 Strasbourg, France. [email protected].
  4. Service de Chirurgie Cardiovasculaire, Pôle de Pathologie Cardiaque, Hôpitaux Universitaires, CHRU Strasbourg, 67000 CEDEX, France. [email protected].
  5. Université de Strasbourg, Fédération de médecine translationnelle de Strasbourg (FMTS), Faculté de Médecine, Equipe d'accueil 3072, 11 Rue Humann, 67000 Strasbourg, France. [email protected].
  6. Université de Strasbourg, Fédération de médecine translationnelle de Strasbourg (FMTS), Faculté de Médecine, Equipe d'accueil 3072, 11 Rue Humann, 67000 Strasbourg, France. [email protected].
  7. Service de Physiologie et d'explorations Fonctionnelles, Hôpitaux Universitaires de Strasbourg, Nouvel Hôpital Civil, 1 place de l'Hôpital, 67091 Strasbourg CEDEX, France. [email protected].
  8. Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz, FIOCRUZ, Avenida Brasil 4365, 21040-360, Rio de Janeiro, Brazil. [email protected].
  9. Instituto Nacional de Cardiologia, Ministério da Saúde, Rua das lanjeiras 374, 22240-006, Rio de Janeiro 22240-006, Brazil. [email protected].
  10. Service de Médecine Interne, Diabète et Maladies Métaboliques, Pôle M.I.R.N.E.D., Hôpitaux Universitaires, CHRU Strasbourg, 67000 CEDEX, France. [email protected].
  11. Université de Strasbourg, Fédération de médecine translationnelle de Strasbourg (FMTS), Faculté de Médecine, Equipe d'accueil 3072, 11 Rue Humann, 67000 Strasbourg, France. [email protected].
  12. Service de Physiologie et d'explorations Fonctionnelles, Hôpitaux Universitaires de Strasbourg, Nouvel Hôpital Civil, 1 place de l'Hôpital, 67091 Strasbourg CEDEX, France. [email protected].

PMID: 31083472 PMCID: PMC6571759 DOI: 10.3390/jcm8050653

Abstract

Peripheral arterial disease (PAD), leading to intermittent claudication, critical ischemia with rest pain, and/or tissue damage, is a public health issue associated with significant morbidity and mortality. Little is known about the link between PAD, cognitive function, and whether exercise might reduce cognitive dysfunction in PAD patients, as previously observed concerning both quality of life and prognosis. This review highlights the fact that patients suffering from PAD often demonstrate cognitive dysfunction characterized by reduced performance in nonverbal reasoning, reduced verbal fluency, and decreased information processing speed and a greater risk for progression toward dementia. Further, the data presented support that physical exercise, likely through myokine secretion and microglial anti-inflammatory phenotype enhancement, might participate in the cognition protection in common clinical settings.

Keywords: BDNF; ankle-brachial index; brain; cathepsin-B; cognitive dysfunction; exercise; irisin; microglia; myokines; peripheral arterial disease

Conflict of interest statement

The authors declare no conflict of interest.

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