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Mihailovici AR, Donoiu I, Gheonea DI, et al. NT-proBNP and Echocardiographic Parameters in Liver Cirrhosis - Correlations with Disease Severity. Med Princ Pract. 2019;doi: 10.1159/000499930.
Mihailovici, A. R., Donoiu, I., Gheonea, D. I., Mirea, O., Târtea, G. C., Buşe, M., Calborean, V., Obleagă, C., Pădureanu, V., & Istrătoaie, O. (2019). NT-proBNP and Echocardiographic Parameters in Liver Cirrhosis - Correlations with Disease Severity. Medical principles and practice : international journal of the Kuwait University, Health Science Centre, . https://doi.org/10.1159/000499930
Mihailovici, Alexandru Radu, et al. "NT-proBNP and Echocardiographic Parameters in Liver Cirrhosis - Correlations with Disease Severity." Medical principles and practice : international journal of the Kuwait University, Health Science Centre vol. (2019). doi: https://doi.org/10.1159/000499930
Mihailovici AR, Donoiu I, Gheonea DI, Mirea O, Târtea GC, Buşe M, Calborean V, Obleagă C, Pădureanu V, Istrătoaie O. NT-proBNP and Echocardiographic Parameters in Liver Cirrhosis - Correlations with Disease Severity. Med Princ Pract. 2019 Apr 16; doi: 10.1159/000499930. Epub 2019 Apr 16. PMID: 30995644; PMCID: PMC6771067.
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Med Princ Pract. 2019 Apr 16; doi: 10.1159/000499930. Epub 2019 Apr 16.

NT-proBNP and Echocardiographic Parameters in Liver Cirrhosis - Correlations with Disease Severity.

Medical principles and practice : international journal of the Kuwait University, Health Science Centre

Alexandru Radu Mihailovici, Ionuț Donoiu, Dan Ionuț Gheonea, Oana Mirea, Georgică Costinel Târtea, Maria Buşe, Veronica Calborean, Cosmin Obleagă, Vlad Pădureanu, Octavian Istrătoaie

PMID: 30995644 PMCID: PMC6771067 DOI: 10.1159/000499930

Abstract

determined. Liver disease severity in patients with cirrhosis was established by Child-Pugh class, MELD score and presence/absence of ascites. Results: Plasma levels of NT-proBNP were significantly higher in cirrhotic patients than in the healthy subjects. NT-proBNP levels were also significantly elevated in Child-Pugh class C patients compared to those in class B and A. Left atrium size, diastolic function, left ventricular wall thickness and left ventricular ejection fraction were significantly altered in cirrhotic patients compared to controls. Advanced cirrhosis and high levels of NT-proBNP were significantly associated with increased left atrium volume and signs of cardiac diastolic dysfunction. We also observed significant differences between quartile groups of MELD score for the following: NT-proBNP, Troponin I, left atrium volume, left ventricle wall thickness, lateral wall and septum systolic tissue doppler velocities and global longitudinal strain. Conclusion: NT-proBNP is increased in patients with cirrhosis and is correlated with the severity of liver disease as established by Child-Pugh class, MELD score and presence of ascites.

The Author(s). Published by S. Karger AG, Basel.

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