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Sandtröm A, Sandberg C, Rinnström D, et al. Factors associated with health-related quality of life among adults with tetralogy of Fallot. Open Heart. 2019;6(1):e000932doi: 10.1136/openhrt-2018-000932.
Sandtröm, A., Sandberg, C., Rinnström, D., Engström, G., Dellborg, M., Thilén, U., Sörensson, P., Nielsen, N. E., Christersson, C., & Johansson, B. (2019). Factors associated with health-related quality of life among adults with tetralogy of Fallot. Open heart, 6(1), e000932. https://doi.org/10.1136/openhrt-2018-000932
Sandtröm, Anette, et al. "Factors associated with health-related quality of life among adults with tetralogy of Fallot." Open heart vol. 6,1 (2019): e000932. doi: https://doi.org/10.1136/openhrt-2018-000932
Sandtröm A, Sandberg C, Rinnström D, Engström G, Dellborg M, Thilén U, Sörensson P, Nielsen NE, Christersson C, Johansson B. Factors associated with health-related quality of life among adults with tetralogy of Fallot. Open Heart. 2019 Feb 27;6(1):e000932. doi: 10.1136/openhrt-2018-000932. eCollection 2019. PMID: 30997127; PMCID: PMC6443137.
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Open Heart. 2019 Feb 27;6(1):e000932. doi: 10.1136/openhrt-2018-000932. eCollection 2019.

Factors associated with health-related quality of life among adults with tetralogy of Fallot.

Open heart

Anette Sandtröm, Camilla Sandberg, Daniel Rinnström, Gunnar Engström, Mikael Dellborg, Ulf Thilén, Peder Sörensson, Niels-Erik Nielsen, Christina Christersson, Bengt Johansson

Affiliations

  1. Heart Centre and Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
  2. Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden.
  3. Department of Cardiology, Clinical Sciences, Lund University, Lund, Sweden.
  4. Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
  5. Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
  6. Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden.

PMID: 30997127 PMCID: PMC6443137 DOI: 10.1136/openhrt-2018-000932

Abstract

BACKGROUND: Due to improved care, the numbers of patients with tetralogy of Fallot (ToF) are increasing. However, long-term morbidity and need for reinterventions are concerns and also address issues of quality of life (QoL).

METHODS: Patients with ToF and valid EuroQol-5 dimensions questionnaire (EQ-5D) were identified in the national Swedish register on congenital heart disease. EQ-5D

RESULTS: 288 patients met the criteria and were analysed. Univariate logistic regression showed a positive association between New York Heart Association (NYHA) class I (OR 8.32, 95% CI 3.80 to 18.21), physical activity >3 h/week (OR 3.34, 95% CI 1.67 to 6.66) and a better right ventricular function (OR 2.56, 95% CI 1.09 to 6.02). A negative association between symptoms (OR 0.23, 95% CI 0.13 to 0.42), cardiovascular medication (OR 0.31, 95% CI 0.18 to 0.53), age (OR 0.97, 95% CI 0.96 to 0.99) and EQ-5D

CONCLUSION: In this registry study, self-reported physical activity, staff-reported NYHA class and absence of symptoms were strongly associated with best possible health-related QoL measured by EQ-5D. Physical activity level is a potential target for intervention to improve QoL in this population but randomised trials are needed to test such a hypothesis.

Keywords: congenital heart disease; physical activity; quality of life; register; tetralogy of fallot

Conflict of interest statement

Competing interests: None declared.

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