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Song P, Cuellar CA, Tang S, et al. Functional Ultrasound Imaging of Spinal Cord Hemodynamic Responses to Epidural Electrical Stimulation: A Feasibility Study. Front Neurol. 2019;10:279doi: 10.3389/fneur.2019.00279.
Song, P., Cuellar, C. A., Tang, S., Islam, R., Wen, H., Huang, C., Manduca, A., Trzasko, J. D., Knudsen, B. E., Lee, K. H., Chen, S., & Lavrov, I. A. (2019). Functional Ultrasound Imaging of Spinal Cord Hemodynamic Responses to Epidural Electrical Stimulation: A Feasibility Study. Frontiers in neurology, 10279. https://doi.org/10.3389/fneur.2019.00279
Song, Pengfei, et al. "Functional Ultrasound Imaging of Spinal Cord Hemodynamic Responses to Epidural Electrical Stimulation: A Feasibility Study." Frontiers in neurology vol. 10 (2019): 279. doi: https://doi.org/10.3389/fneur.2019.00279
Song P, Cuellar CA, Tang S, Islam R, Wen H, Huang C, Manduca A, Trzasko JD, Knudsen BE, Lee KH, Chen S, Lavrov IA. Functional Ultrasound Imaging of Spinal Cord Hemodynamic Responses to Epidural Electrical Stimulation: A Feasibility Study. Front Neurol. 2019 Mar 26;10:279. doi: 10.3389/fneur.2019.00279. eCollection 2019. PMID: 30972010; PMCID: PMC6445046.
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Front Neurol. 2019 Mar 26;10:279. doi: 10.3389/fneur.2019.00279. eCollection 2019.

Functional Ultrasound Imaging of Spinal Cord Hemodynamic Responses to Epidural Electrical Stimulation: A Feasibility Study.

Frontiers in neurology

Pengfei Song, Carlos A Cuellar, Shanshan Tang, Riazul Islam, Hai Wen, Chengwu Huang, Armando Manduca, Joshua D Trzasko, Bruce E Knudsen, Kendall H Lee, Shigao Chen, Igor A Lavrov

Affiliations

  1. Department of Radiology, Mayo Clinic, Rochester, MN, United States.
  2. Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, United States.
  3. Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, United States.
  4. Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, United States.
  5. Department of Neurology, Mayo Clinic, Rochester, MN, United States.
  6. Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia.

PMID: 30972010 PMCID: PMC6445046 DOI: 10.3389/fneur.2019.00279

Abstract

This study presents the first implementation of functional ultrasound (fUS) imaging of the spinal cord to monitor local hemodynamic response to epidural electrical spinal cord stimulation (SCS) on two small and large animal models. SCS has been successfully applied to control chronic refractory pain and recently was evolved to alleviate motor impairment in Parkinson's disease and after spinal cord injury. At present, however, the mechanisms underlying SCS remain unclear, and current methods for monitoring SCS are limited in their capacity to provide the required sensitivity and spatiotemporal resolutions to evaluate functional changes in response to SCS. fUS is an emerging technology that has recently shown promising results in monitoring a variety of neural activities associated with the brain. Here we demonstrated the feasibility of performing fUS on two animal models during SCS. We showed

Keywords: electrical stimulation; functional ultrasound; hemodynamic responses; spinal cord; spinal cord injury; ultrafast imaging

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