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Akther J, Nabi AHMN, Ohno S, et al. Establishing a novel assay system for measuring renin concentration using cost effective recombinant ovine angiotensinogen. Heliyon. 2019;5(4):e01409doi: 10.1016/j.heliyon.2019.e01409.
Akther, J., Nabi, A. H. M. N., Ohno, S., Yokogawa, T., Nakagawa, T., Suzuki, F., & Ebihara, A. (2019). Establishing a novel assay system for measuring renin concentration using cost effective recombinant ovine angiotensinogen. Heliyon, 5(4), e01409. https://doi.org/10.1016/j.heliyon.2019.e01409
Akther, Jobaida, et al. "Establishing a novel assay system for measuring renin concentration using cost effective recombinant ovine angiotensinogen." Heliyon vol. 5,4 (2019): e01409. doi: https://doi.org/10.1016/j.heliyon.2019.e01409
Akther J, Nabi AHMN, Ohno S, Yokogawa T, Nakagawa T, Suzuki F, Ebihara A. Establishing a novel assay system for measuring renin concentration using cost effective recombinant ovine angiotensinogen. Heliyon. 2019 Apr 04;5(4):e01409. doi: 10.1016/j.heliyon.2019.e01409. eCollection 2019 Apr. PMID: 30997427; PMCID: PMC6451169.
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Heliyon. 2019 Apr 04;5(4):e01409. doi: 10.1016/j.heliyon.2019.e01409. eCollection 2019 Apr.

Establishing a novel assay system for measuring renin concentration using cost effective recombinant ovine angiotensinogen.

Heliyon

Jobaida Akther, A H M Nurun Nabi, Satoshi Ohno, Takashi Yokogawa, Tsutomu Nakagawa, Fumiaki Suzuki, Akio Ebihara

Affiliations

  1. United Graduate School of Agricultural Science, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan.
  2. Laboratory of Population Genetics, Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka, 1000, Bangladesh.
  3. Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan.
  4. Center for Highly Advanced Integration of Nano and Life Sciences, Gifu University (G-CHAIN), 1-1 Yanagido, Gifu, 501-1193, Japan.
  5. Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan.

PMID: 30997427 PMCID: PMC6451169 DOI: 10.1016/j.heliyon.2019.e01409

Abstract

BACKGROUND: Plasma renin can predict future cardiovascular events as well as the prevalence of chronic renal disease in hypertensive subjects. Ovine angiotensinogen (oANG) is a better substrate for measuring renin concentration through activity assay. Recombinant oANG expressed in

MATERIAL AND METHODS: Recombinant oANG was expressed in

RESULTS: About 4.5 mg of purified recombinant oANG was obtained from 0.5 L of

CONCLUSION: This study established a novel assay system for measuring renin at picomolar level using cost effective recombinant oANG.

Keywords: Biochemistry; Biotechnology; Immunology

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