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Li J, Yuan X, March ME, et al. Identification of Target Genes at Juvenile Idiopathic Arthritis GWAS Loci in Human Neutrophils. Front Genet. 2019;10:181doi: 10.3389/fgene.2019.00181.
Li, J., Yuan, X., March, M. E., Yao, X., Sun, Y., Chang, X., Hakonarson, H., Xia, Q., Meng, X., & Li, J. (2019). Identification of Target Genes at Juvenile Idiopathic Arthritis GWAS Loci in Human Neutrophils. Frontiers in genetics, 10181. https://doi.org/10.3389/fgene.2019.00181
Li, Junyi, et al. "Identification of Target Genes at Juvenile Idiopathic Arthritis GWAS Loci in Human Neutrophils." Frontiers in genetics vol. 10 (2019): 181. doi: https://doi.org/10.3389/fgene.2019.00181
Li J, Yuan X, March ME, Yao X, Sun Y, Chang X, Hakonarson H, Xia Q, Meng X, Li J. Identification of Target Genes at Juvenile Idiopathic Arthritis GWAS Loci in Human Neutrophils. Front Genet. 2019 Mar 27;10:181. doi: 10.3389/fgene.2019.00181. eCollection 2019. PMID: 30972099; PMCID: PMC6445851.
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Front Genet. 2019 Mar 27;10:181. doi: 10.3389/fgene.2019.00181. eCollection 2019.

Identification of Target Genes at Juvenile Idiopathic Arthritis GWAS Loci in Human Neutrophils.

Frontiers in genetics

Junyi Li, Xiucheng Yuan, Michael E March, Xueming Yao, Yan Sun, Xiao Chang, Hakon Hakonarson, Qianghua Xia, Xinyi Meng, Jin Li

Affiliations

  1. Department of Cell Biology, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Key Laboratory of Medical Epigenetics, Tianjin Medical University, Tianjin, China.
  2. Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
  3. Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
  4. Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.

PMID: 30972099 PMCID: PMC6445851 DOI: 10.3389/fgene.2019.00181

Abstract

Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease among children which could cause severe disability. Genomic studies have discovered substantial number of risk loci for JIA, however, the mechanism of how these loci affect JIA development is not fully understood. Neutrophil is an important cell type involved in autoimmune diseases. To better understand the biological function of genetic loci in neutrophils during JIA development, we took an integrated multi-omics approach to identify target genes at JIA risk loci in neutrophils and constructed a protein-protein interaction network via a machine learning approach. We identified genes likely to be JIA risk loci targeted genes in neutrophils which could contribute to JIA development.

Keywords: epigenetic regulation; juvenile idiopathic arthritis; pathway enrichment; protein-protein interaction; target gene identification

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