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Simakova M, Tobiasz A, Sullivan RD, et al. Gestational Age-Dependent Interplay between Endocannabinoid Receptors and Alcohol in Fetal Cerebral Arteries. J Drug Alcohol Res. 2019;8doi: 10.4303/jdar/236068.
Simakova, M., Tobiasz, A., Sullivan, R. D., Bisen, S., Duncan, J., Sullivan, J. P., Davison, S., Tate, D. L., Barnett, S., Mari, G., Dopico, A. M., & Bukiya, A. N. (2019). Gestational Age-Dependent Interplay between Endocannabinoid Receptors and Alcohol in Fetal Cerebral Arteries. Journal of drug and alcohol research, 8. https://doi.org/10.4303/jdar/236068
Simakova, Maria, et al. "Gestational Age-Dependent Interplay between Endocannabinoid Receptors and Alcohol in Fetal Cerebral Arteries." Journal of drug and alcohol research vol. 8 (2019). doi: https://doi.org/10.4303/jdar/236068
Simakova M, Tobiasz A, Sullivan RD, Bisen S, Duncan J, Sullivan JP, Davison S, Tate DL, Barnett S, Mari G, Dopico AM, Bukiya AN. Gestational Age-Dependent Interplay between Endocannabinoid Receptors and Alcohol in Fetal Cerebral Arteries. J Drug Alcohol Res. 2019;8. doi: 10.4303/jdar/236068. PMID: 31057979; PMCID: PMC6497414.
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J Drug Alcohol Res. 2019;8. doi: 10.4303/jdar/236068.

Gestational Age-Dependent Interplay between Endocannabinoid Receptors and Alcohol in Fetal Cerebral Arteries.

Journal of drug and alcohol research

Maria Simakova, Ana Tobiasz, Ryan D Sullivan, Shivantika Bisen, Jose Duncan, J Pierce Sullivan, Steven Davison, Danielle L Tate, Stacey Barnett, Giancarlo Mari, Alex M Dopico, Anna N Bukiya

Affiliations

  1. Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN, USA.
  2. Department of Obstetrics and Gynecology, University of Tennessee Health Science Center, Memphis, TN, USA.
  3. Department of Comparative Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.

PMID: 31057979 PMCID: PMC6497414 DOI: 10.4303/jdar/236068

Abstract

Alcohol (ethanol) is one of the most widely consumed drugs. Alcohol consumption by pregnant women may result in a range of fetal abnormalities termed fetal alcohol spectrum disorders (FASDs). The cerebrovascular system is emerging as a critical target of alcohol in the developing brain. We recently showed that three episodes of prenatal alcohol exposure resulting in 80 mg/dL alcohol in maternal blood during mid-pregnancy up-regulated anandamide-induced dilation of fetal cerebral arteries. Moreover, ethanol dilated fetal cerebral arteries via cannabinoid (CB) receptors. Whether a critical role of fetal cerebral artery CB system in responses to alcohol was maintained throughout the gestation, remains unknow.

MAIN METHODS: Pregnant baboons (second trimester equivalent) were subjected to three episodes of either alcohol or control drink infusion via gavage. Cerebral arteries from mothers and near-term female fetuses were

KEY FINDINGS: Near-term fetal and maternal arteries exhibited similar ability to develop myogenic tone, to constrict in presence of 60 mM KCl, and to respond to 10 µM anandamide. Fetal and maternal arteries largely failed to dilate in presence of 63 mM ethanol. No differences were detected between arteries from control and alcohol-exposed baboon donors. Therefore, previously observed ethanol-induced dilation of fetal cerebral arteries and up-regulation of CB components in response to fetal alcohol exposure during mid-pregnancy was transient and disappeared by near-term.

Keywords: cannabinoid receptor; cannabinoid system; fetal cerebral artery; maternal alcohol consumption; prenatal alcohol

References

  1. Br J Pharmacol. 1999 Feb;126(3):665-72 - PubMed
  2. Am J Physiol Regul Integr Comp Physiol. 2000 Sep;279(3):R860-73 - PubMed
  3. Am J Physiol Regul Integr Comp Physiol. 2002 Jan;282(1):R131-8 - PubMed
  4. Pharmacol Ther. 2003 Dec;100(3):235-55 - PubMed
  5. Eur J Pharmacol. 2004 Oct 1;500(1-3):289-97 - PubMed
  6. Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):18217-22 - PubMed
  7. Am J Physiol Heart Circ Physiol. 2006 Aug;291(2):H732-40 - PubMed
  8. Neuroscientist. 2007 Apr;13(2):109-14 - PubMed
  9. Exp Physiol. 2007 Sep;92(5):933-43 - PubMed
  10. Neuroimage. 2008 Mar 1;40(1):148-59 - PubMed
  11. Appl Physiol Nutr Metab. 2008 Feb;33(1):12-20 - PubMed
  12. Clin Obstet Gynecol. 2008 Jun;51(2):436-44 - PubMed
  13. Mini Rev Med Chem. 2009 Apr;9(4):448-62 - PubMed
  14. FEBS Lett. 2009 Sep 3;583(17):2779-84 - PubMed
  15. Vitam Horm. 2009;81:139-58 - PubMed
  16. Neuroreport. 2010 Jul 14;21(10):716-21 - PubMed
  17. Neuroscience. 2010 Sep 29;170(1):28-41 - PubMed
  18. Neuropsychol Rev. 2011 Jun;21(2):73-80 - PubMed
  19. Br J Pharmacol. 2012 Apr;165(8):2561-74 - PubMed
  20. J Psychopharmacol. 2012 Jan;26(1):164-76 - PubMed
  21. Arterioscler Thromb Vasc Biol. 2011 Nov;31(11):2410-23 - PubMed
  22. Alcohol Clin Exp Res. 2012 May;36(5):748-58 - PubMed
  23. Life Sci. 2013 Mar 19;92(8-9):476-81 - PubMed
  24. Philos Trans R Soc Lond B Biol Sci. 2012 Dec 5;367(1607):3326-41 - PubMed
  25. Med Sci Law. 1990 Apr;30(2):101-5 - PubMed
  26. Paediatr Anaesth. 2014 Jan;24(1):22-9 - PubMed
  27. FEBS Lett. 2014 May 2;588(9):1659-65 - PubMed
  28. Contraception. 2015 Aug;92(2):120-3 - PubMed
  29. Alcohol Clin Exp Res. 2017 Jan;41(1):117-127 - PubMed
  30. Alcohol. 2017 Jun;61:51-61 - PubMed
  31. JAMA Pediatr. 2017 Oct 1;171(10):948-956 - PubMed
  32. Reprod Sci. 2018 Jul;25(7):1116-1123 - PubMed
  33. Clin Auton Res. 2018 Feb;28(1):35-52 - PubMed
  34. J Drug Alcohol Res. 2016;5:null - PubMed
  35. Alcohol Clin Exp Res. 2018 Jun;42(6):1006-1018 - PubMed
  36. Alcohol. 1984 Jul-Aug;1(4):325-31 - PubMed
  37. Perspect Dev Neurobiol. 1995;2(4):309-15 - PubMed
  38. Eur J Pharmacol. 1996 Jul 4;307(3):331-8 - PubMed
  39. J Physiol. 1996 Apr 15;492 ( Pt 2):419-30 - PubMed

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