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Qiu S, Cai X, Liu J, et al. Association Between Cardiorespiratory Fitness and Risk of Heart Failure: A Meta-Analysis. J Card Fail. 2019;25(7):537-544doi: 10.1016/j.cardfail.2019.04.008.
Qiu, S., Cai, X., Liu, J., Yang, B., Sun, Z., Zügel, M., Steinacker, J. M., & Schumann, U. (2019). Association Between Cardiorespiratory Fitness and Risk of Heart Failure: A Meta-Analysis. Journal of cardiac failure, 25(7), 537-544. https://doi.org/10.1016/j.cardfail.2019.04.008
Qiu, Shanhu, et al. "Association Between Cardiorespiratory Fitness and Risk of Heart Failure: A Meta-Analysis." Journal of cardiac failure vol. 25,7 (2019): 537-544. doi: https://doi.org/10.1016/j.cardfail.2019.04.008
Qiu S, Cai X, Liu J, Yang B, Sun Z, Zügel M, Steinacker JM, Schumann U. Association Between Cardiorespiratory Fitness and Risk of Heart Failure: A Meta-Analysis. J Card Fail. 2019 Jul;25(7):537-544. doi: 10.1016/j.cardfail.2019.04.008. Epub 2019 Apr 08. PMID: 30974161.
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J Card Fail. 2019 Jul;25(7):537-544. doi: 10.1016/j.cardfail.2019.04.008. Epub 2019 Apr 08.

Association Between Cardiorespiratory Fitness and Risk of Heart Failure: A Meta-Analysis.

Journal of cardiac failure

Shanhu Qiu, Xue Cai, Jianing Liu, Bingquan Yang, Zilin Sun, Martina Zügel, Jürgen Michael Steinacker, Uwe Schumann

Affiliations

  1. Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, School of Medicine, Southeast University, Nanjing, P.R. China; Division of Sports and Rehabilitation Medicine, Ulm University Medical Center, Ulm, Germany.
  2. School of Nursing, Peking University, Beijing, China.
  3. Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, School of Medicine, Southeast University, Nanjing, P.R. China.
  4. Division of Sports and Rehabilitation Medicine, Ulm University Medical Center, Ulm, Germany. Electronic address: [email protected].
  5. Division of Sports and Rehabilitation Medicine, Ulm University Medical Center, Ulm, Germany.

PMID: 30974161 DOI: 10.1016/j.cardfail.2019.04.008

Abstract

BACKGROUND: Evidence emerges that cardiorespiratory fitness (CRF) might be implicated in the development of heart failure (HF). This meta-analysis aimed to quantify the association between CRF exposed at baseline and HF risk with dose-response analysis and to assess whether CRF changes over time are correlated with alterations in HF risk.

METHODS AND RESULTS: Cohort studies that assessed the association between CRF and risk of HF in subjects without baseline HF were included. Study-specific multivariate-adjusted relative risks (RRs) with 95% confidence intervals (CIs) were pooled using a random-effects model. Ten studies from 8 articles were included, enrolling 8987 incident HF cases from 154,598 participants. The RR of HF per 1-metabolic equivalent (MET) higher CRF at baseline was 0.82 (95% CI 0.80-0.84) in the overall population. The RRs were similar in men (0.82, 95% CI 0.80-0.85) and women (0.81, 95% CI 0.78-0.84), and remained minorly changed in patients with existing diabetes, hypertension, or cardiovascular disease at entry. No evidence of a nonlinear relationship between CRF at baseline and risk of HF was observed (P

CONCLUSIONS: High or increased CRF resulted in reduced risk of HF in a dose-dependent manner, supporting the necessity to increase CRF to prevent HF in clinical practice.

Copyright © 2019 Elsevier Inc. All rights reserved.

Keywords: Cardiorespiratory fitness; heart failure; meta-analysis

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