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Weber B, Seidl C, Schwiertz D, et al. Polysarcosine-Based Lipids: From Lipopolypeptoid Micelles to Stealth-Like Lipids in Langmuir Blodgett Monolayers. Polymers (Basel). 2016;8(12)doi: 10.3390/polym8120427.
Weber, B., Seidl, C., Schwiertz, D., Scherer, M., Bleher, S., Süss, R., & Barz, M. (2016). Polysarcosine-Based Lipids: From Lipopolypeptoid Micelles to Stealth-Like Lipids in Langmuir Blodgett Monolayers. Polymers, 8(12), . https://doi.org/10.3390/polym8120427
Weber, Benjamin, et al. "Polysarcosine-Based Lipids: From Lipopolypeptoid Micelles to Stealth-Like Lipids in Langmuir Blodgett Monolayers." Polymers vol. 8,12 (2016). doi: https://doi.org/10.3390/polym8120427
Weber B, Seidl C, Schwiertz D, Scherer M, Bleher S, Süss R, Barz M. Polysarcosine-Based Lipids: From Lipopolypeptoid Micelles to Stealth-Like Lipids in Langmuir Blodgett Monolayers. Polymers (Basel). 2016 Dec 09;8(12). doi: 10.3390/polym8120427. PMID: 30974703; PMCID: PMC6432249.
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Polymers (Basel). 2016 Dec 09;8(12). doi: 10.3390/polym8120427.

Polysarcosine-Based Lipids: From Lipopolypeptoid Micelles to Stealth-Like Lipids in Langmuir Blodgett Monolayers.

Polymers

Benjamin Weber, Christine Seidl, David Schwiertz, Martin Scherer, Stefan Bleher, Regine Süss, Matthias Barz

Affiliations

  1. Institute of Organic Chemistry, Johannes Gutenberg University of Mainz, Duesbergweg 10-14, 55128 Mainz, Germany. [email protected].
  2. Institute of Organic Chemistry, Johannes Gutenberg University of Mainz, Duesbergweg 10-14, 55128 Mainz, Germany. [email protected].
  3. Institute of Organic Chemistry, Johannes Gutenberg University of Mainz, Duesbergweg 10-14, 55128 Mainz, Germany. [email protected].
  4. Institute of Organic Chemistry, Johannes Gutenberg University of Mainz, Duesbergweg 10-14, 55128 Mainz, Germany. [email protected].
  5. Department of Pharmaceutical Technology and Biopharmacy, Institute of Pharmaceutical Sciences, Albert Ludwigs University of Freiburg, Sonnenstraße 5, 79104 Freiburg im Breisgau, Germany. [email protected].
  6. Department of Pharmaceutical Technology and Biopharmacy, Institute of Pharmaceutical Sciences, Albert Ludwigs University of Freiburg, Sonnenstraße 5, 79104 Freiburg im Breisgau, Germany. [email protected].
  7. Institute of Organic Chemistry, Johannes Gutenberg University of Mainz, Duesbergweg 10-14, 55128 Mainz, Germany. [email protected].

PMID: 30974703 PMCID: PMC6432249 DOI: 10.3390/polym8120427

Abstract

Amphiphiles and, in particular, PEGylated lipids or alkyl ethers represent an important class of non-ionic surfactants and have become key ingredients for long-circulating ("stealth") liposomes. While poly-(ethylene glycol) (PEG) can be considered the gold standard for stealth-like materials, it is known to be neither a bio-based nor biodegradable material. In contrast to PEG, polysarcosine (PSar) is based on the endogenous amino acid sarcosine (

Keywords: NCA polymerization; PSarcosinylated lipids; lipids; polypeptoids; polysarcosine; surfactants

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