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Recchiuti A, Mattoscio D, Isopi E. Roles, Actions, and Therapeutic Potential of Specialized Pro-resolving Lipid Mediators for the Treatment of Inflammation in Cystic Fibrosis. Front Pharmacol. 2019;10:252doi: 10.3389/fphar.2019.00252.
Recchiuti, A., Mattoscio, D., & Isopi, E. (2019). Roles, Actions, and Therapeutic Potential of Specialized Pro-resolving Lipid Mediators for the Treatment of Inflammation in Cystic Fibrosis. Frontiers in pharmacology, 10252. https://doi.org/10.3389/fphar.2019.00252
Recchiuti, Antonio, et al. "Roles, Actions, and Therapeutic Potential of Specialized Pro-resolving Lipid Mediators for the Treatment of Inflammation in Cystic Fibrosis." Frontiers in pharmacology vol. 10 (2019): 252. doi: https://doi.org/10.3389/fphar.2019.00252
Recchiuti A, Mattoscio D, Isopi E. Roles, Actions, and Therapeutic Potential of Specialized Pro-resolving Lipid Mediators for the Treatment of Inflammation in Cystic Fibrosis. Front Pharmacol. 2019 Apr 02;10:252. doi: 10.3389/fphar.2019.00252. eCollection 2019. PMID: 31001110; PMCID: PMC6454233.
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Front Pharmacol. 2019 Apr 02;10:252. doi: 10.3389/fphar.2019.00252. eCollection 2019.

Roles, Actions, and Therapeutic Potential of Specialized Pro-resolving Lipid Mediators for the Treatment of Inflammation in Cystic Fibrosis.

Frontiers in pharmacology

Antonio Recchiuti, Domenico Mattoscio, Elisa Isopi

Affiliations

  1. Department of Medical, Oral and Biotechnological Science, Università "G. d'Annunzio" Chieti-Pescara, Chieti, Italy.
  2. Centro di Scienze dell'Invecchiamento e Medicina Traslazionale (CeSI-MeT), Università "G. d'Annunzio" Chieti-Pescara, Chieti, Italy.

PMID: 31001110 PMCID: PMC6454233 DOI: 10.3389/fphar.2019.00252

Abstract

Non-resolving inflammation is the main mechanism of morbidity and mortality among patients suffering from cystic fibrosis (CF), the most common life-threatening human genetic disease. Resolution of inflammation is an active process timely controlled by endogenous specialized pro-resolving lipid mediators (SPMs) produced locally in inflammatory loci to restrain this innate response, prevent further damages to the host, and permit return to homeostasis. Lipoxins, resolvins, protectins, and maresins are SPM derived from polyunsaturated fatty acids that limit excessive leukocyte infiltration and pro-inflammatory signals, stimulate innate microbial killing, and enhance resolution. Their unique chemical structures, receptors, and bioactions are being elucidated. Accruing data indicate that SPMs carry protective functions against unrelenting inflammation and infections in preclinical models and human CF systems. Here, we reviewed their roles and actions in controlling resolution of inflammation, evidence for their impairment in CF, and proofs of principle for their exploitation as innovative, non-immunosuppressive drugs to address inflammation and infections in CF.

Keywords: Pseudomonas aeruginosa; chronic infections; homeostasis; lipid mediator; lung inflammation and fibrosis; macrophages; pharmacology; resolution

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