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Cheong KH, Koh JM, Jones MC. Black Swans of CRISPR: Stochasticity and Complexity of Genetic Regulation. Bioessays. 2019;41(7):e1900032doi: 10.1002/bies.201900032.
Cheong, K. H., Koh, J. M., & Jones, M. C. (2019). Black Swans of CRISPR: Stochasticity and Complexity of Genetic Regulation. BioEssays : news and reviews in molecular, cellular and developmental biology, 41(7), e1900032. https://doi.org/10.1002/bies.201900032
Cheong, Kang Hao, et al. "Black Swans of CRISPR: Stochasticity and Complexity of Genetic Regulation." BioEssays : news and reviews in molecular, cellular and developmental biology vol. 41,7 (2019): e1900032. doi: https://doi.org/10.1002/bies.201900032
Cheong KH, Koh JM, Jones MC. Black Swans of CRISPR: Stochasticity and Complexity of Genetic Regulation. Bioessays. 2019 Jul;41(7):e1900032. doi: 10.1002/bies.201900032. Epub 2019 May 15. PMID: 31090950.
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Bioessays. 2019 Jul;41(7):e1900032. doi: 10.1002/bies.201900032. Epub 2019 May 15.

Black Swans of CRISPR: Stochasticity and Complexity of Genetic Regulation.

BioEssays : news and reviews in molecular, cellular and developmental biology

Kang Hao Cheong, Jin Ming Koh, Michael C Jones

Affiliations

  1. Science and Math Cluster, Singapore University of Technology and Design, 8 Somapah Road, Singapore, 487372, Singapore.
  2. PO Box 432, Ashland, Columbia, MO, 65010, USA.

PMID: 31090950 DOI: 10.1002/bies.201900032

Abstract

Recent waves of controversies surrounding genetic engineering have spilled into popular science in Twitter battles between reputable scientists and their followers. Here, a cautionary perspective on the possible blind spots and risks of CRISPR and related biotechnologies is presented, focusing in particular on the stochastic nature of cellular control processes.

© 2019 WILEY Periodicals, Inc.

Keywords: CRISPR; biotechnology; gene regulatory networks; genetic editing; noise; nonlinear dynamics; stochasticity

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