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Ureña-Torres PA, Vervloet M, Mazzaferro S, et al. Novel insights into parathyroid hormone: report of The Parathyroid Day in Chronic Kidney Disease. Clin Kidney J. 2018;12(2):269-280doi: 10.1093/ckj/sfy061.
Ureña-Torres, P. A., Vervloet, M., Mazzaferro, S., Oury, F., Brandenburg, V., Bover, J., Cavalier, E., Cohen-Solal, M., Covic, A., Drüeke, T. B., Hindié, E., Evenepoel, P., Frazão, J., Goldsmith, D., Kazama, J. J., Cozzolino, M., Massy, Z. A. (2019). Novel insights into parathyroid hormone: report of The Parathyroid Day in Chronic Kidney Disease. Clinical kidney journal, 12(2), 269-280. https://doi.org/10.1093/ckj/sfy061
Ureña-Torres, Pablo A, et al. "Novel insights into parathyroid hormone: report of The Parathyroid Day in Chronic Kidney Disease." Clinical kidney journal vol. 12,2 (2019): 269-280. doi: https://doi.org/10.1093/ckj/sfy061
Ureña-Torres PA, Vervloet M, Mazzaferro S, Oury F, Brandenburg V, Bover J, Cavalier E, Cohen-Solal M, Covic A, Drüeke TB, Hindié E, Evenepoel P, Frazão J, Goldsmith D, Kazama JJ, Cozzolino M, Massy ZA. Novel insights into parathyroid hormone: report of The Parathyroid Day in Chronic Kidney Disease. Clin Kidney J. 2018 Jul 20;12(2):269-280. doi: 10.1093/ckj/sfy061. eCollection 2019 Apr. PMID: 30976408; PMCID: PMC6452197.
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Clin Kidney J. 2018 Jul 20;12(2):269-280. doi: 10.1093/ckj/sfy061. eCollection 2019 Apr.

Novel insights into parathyroid hormone: report of The Parathyroid Day in Chronic Kidney Disease.

Clinical kidney journal

Pablo A Ureña-Torres, Marc Vervloet, Sandro Mazzaferro, Franck Oury, Vincent Brandenburg, Jordi Bover, Etienne Cavalier, Martine Cohen-Solal, Adrian Covic, Tilman B Drüeke, Elif Hindié, Pieter Evenepoel, João Frazão, David Goldsmith, Junichiro James Kazama, Mario Cozzolino, Ziad A Massy,

Affiliations

  1. Ramsay-Générale de Santé, Clinique du Landy, Department of Nephrology and Dialysis and Department of Renal Physiology, Necker Hospital, University of Paris Descartes, Paris, France.
  2. Department of Nephrology and Amsterdam Cardiovascular Sciences (ACS), VU University Medical Center, Amsterdam, The Netherlands.
  3. Department of Cardiovascular Respiratory Nephrologic Anaesthetic and Geriatric Sciences, Sapienza University of Rome, Rome, Italy.
  4. INEM, Centre de Mdecine Moléculaire Faculté de Médecine Paris Descartes, Sorbonne, Paris Cité Bâtiment Leriche, France.
  5. Department of Cardiology, University Hospital RWTH Aachen, Pauwelsstraße, Aachen, Germany.
  6. Department of Nephrology, Fundació Puigvert, IIB Sant Pau, RedinRen, C. Cartagena, Catalonia, 340-350 Barcelona, Spain.
  7. Department of Clinical Chemistry, University of Liège, CHU Sart-Tilman, Liège, Belgium.
  8. INSERM U1132 & USPC Paris-Diderot, Department of Rheumatology, Hôpital Lariboisière, Paris, France.
  9. Department of Nephrology, University of Medicine and Pharmacy "Gr. T. Popa", Iasi, Romania.
  10. Inserm Unit 1018, CESP, Team 5, Paul Brousse Hospital, Villejuif/Paris, France.
  11. Nuclear Medicine, University of Bordeaux, Haut-Lévêque Hospital, Pessac, France.
  12. Department of Medicine, Division of Nephrology, University Hospital Leuven, Leuven, Belgium.
  13. Dienst nefrologie, Universitair Ziekenhuis Gasthuisberg, Herestraat, Leuven, Belgium.
  14. Institute of Investigation and Innovation in Health, University of Porto, Porto, Portugal.
  15. INEB-National Institute of Biomedical Engineer, University of Porto, Porto, Portugal.
  16. Department of Nephrology, São João Hospital Center, Porto, Portugal.
  17. School of Medicine of University of Porto, Porto, Portugal.
  18. Guy's and St Thomas' Hospitals, London, UK.
  19. Department of Nephrology and Hypertension, Fukushima Medical University, 1 Hikarigaoka, Fukushima 960-1247, Japan.
  20. Renal Division, San Paolo Hospital, Department of Health Sciences, University of Milan, Milan, Italy.
  21. Division of Nephrology, Ambroise Paré University Medical Center, APHP, University of Paris Ouest (UVSQ), Boulogne Billancourt/Paris, France.

PMID: 30976408 PMCID: PMC6452197 DOI: 10.1093/ckj/sfy061

Abstract

Chronic kidney disease (CKD) is often associated with a mineral and bone disorder globally described as CKD-Mineral and Bone Disease (MBD), including renal osteodystrophy, the latter ranging from high bone turnover, as in case of secondary hyperparathyroidism (SHPT), to low bone turnover. The present article summarizes the important subjects that were covered during 'The Parathyroid Day in Chronic Kidney Disease' CME course organized in Paris in September 2017. It includes the latest insights on parathyroid gland growth, parathyroid hormone (PTH) synthesis, secretion and regulation by the calcium-sensing receptor, vitamin D receptor and fibroblast growth factor 23 (FGF23)-Klotho axis, as well as on parathyroid glands imaging. The skeletal action of PTH in early CKD stages to the steadily increasing activation of the often downregulated PTH receptor type 1 has been critically reviewed, emphasizing that therapeutic strategies to decrease PTH levels at these stages might not be recommended. The effects of PTH on the central nervous system, in particular cognitive functions, and on the cardiovascular system are revised, and the reliability and exchangeability of second- and third-generation PTH immunoassays discussed. The article also reviews the different circulating biomarkers used for the diagnosis and monitoring of CKD-MBD, including PTH and alkaline phosphatases isoforms. Moreover, it presents an update on the control of SHPT by vitamin D compounds, old and new calcimimetics, and parathyroidectomy. Finally, it covers the latest insights on the persistence and

Keywords: CKD; calcium; hyperparathyroidism; phosphataemia; vitamin D

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