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Jamal A, Fatima N, Shaikh S, et al. Pattern of Antimicrobial Sensitivity in Microbiologically Documented Infections in Neutropenic Patients with Haematological Malignancies: A single Center Study. Indian J Microbiol. 2019;59(2):188-192doi: 10.1007/s12088-019-00789-y.
Jamal, A., Fatima, N., Shaikh, S., Kaleem, B., Rizvi, Q. A., Zaidi, U., Borhany, M., & Shamsi, T. (2019). Pattern of Antimicrobial Sensitivity in Microbiologically Documented Infections in Neutropenic Patients with Haematological Malignancies: A single Center Study. Indian journal of microbiology, 59(2), 188-192. https://doi.org/10.1007/s12088-019-00789-y
Jamal, Aisha, et al. "Pattern of Antimicrobial Sensitivity in Microbiologically Documented Infections in Neutropenic Patients with Haematological Malignancies: A single Center Study." Indian journal of microbiology vol. 59,2 (2019): 188-192. doi: https://doi.org/10.1007/s12088-019-00789-y
Jamal A, Fatima N, Shaikh S, Kaleem B, Rizvi QA, Zaidi U, Borhany M, Shamsi T. Pattern of Antimicrobial Sensitivity in Microbiologically Documented Infections in Neutropenic Patients with Haematological Malignancies: A single Center Study. Indian J Microbiol. 2019 Jun;59(2):188-192. doi: 10.1007/s12088-019-00789-y. Epub 2019 Mar 04. PMID: 31031433; PMCID: PMC6458217.
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Indian J Microbiol. 2019 Jun;59(2):188-192. doi: 10.1007/s12088-019-00789-y. Epub 2019 Mar 04.

Pattern of Antimicrobial Sensitivity in Microbiologically Documented Infections in Neutropenic Patients with Haematological Malignancies: A single Center Study.

Indian journal of microbiology

Aisha Jamal, Naveena Fatima, Sajjad Shaikh, Bushra Kaleem, Qurratul Ain Rizvi, Uzma Zaidi, Munira Borhany, Tahir Shamsi

Affiliations

  1. 1Department of Clinical Haematology and BMT, National Institute of Blood Disease & Bone Marrow Transplantation, Karachi, Pakistan.
  2. 2Department of Clinical Research & Development, National Institute of Blood Disease & Bone Marrow Transplantation, Karachi, Pakistan.
  3. 3Department of Microbiology, National Institute of Blood Disease & Bone Marrow Transplantation, Karachi, Pakistan.

PMID: 31031433 PMCID: PMC6458217 DOI: 10.1007/s12088-019-00789-y

Abstract

Febrile neutropenia is a medical emergency that complicates the clinical course and treatment of haematological malignancies, significantly enhancing the financial burden and worsening the overall outcome. This study was carried out to evaluate the efficacy of institution's current first-line antibiotic regimen for febrile neutropenia in view of recent spectrum of institution's local flora and its susceptibility pattern. 163 episodes of microbiologically documented infections in 110 adult patients were studied over a period of 1 year. Of 110 patients, 61 patients were male. The mean age of the patient population, mean absolute neutrophil count and temperature as documented were 30.1 years (SD ± 16.8), 450 cells/ul, and 101.9 °C respectively. Gram-negative and gram-positive organisms accounted for 79% and 21% of the febrile neutropenic infections respectively.

Keywords: Antibiotic sensitivity; Febrile neutropenia; Haematological malignancies; Microbiological spectrum; Microbiologically documented infections

Conflict of interest statement

The authors declare that they have no conflict of interest.This study was approved by the Institutional Review Board and informed consent was taken from the participants prior to the study.

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