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Blain H, Sinaii N, Zeltser D, et al. Aortic pulse wave velocity in children with Cushing syndrome: A window into a marker of early cardiovascular disease. Endocrinol Diabetes Metab. 2019;2(2):e00054doi: 10.1002/edm2.54.
Blain, H., Sinaii, N., Zeltser, D., Lyssikatos, C., Belyavskaya, E., Keil, M., Bluemke, D. A., Stratakis, C., Bandettini, W. P., & Lodish, M. (2019). Aortic pulse wave velocity in children with Cushing syndrome: A window into a marker of early cardiovascular disease. Endocrinology, diabetes & metabolism, 2(2), e00054. https://doi.org/10.1002/edm2.54
Blain, Hailey, et al. "Aortic pulse wave velocity in children with Cushing syndrome: A window into a marker of early cardiovascular disease." Endocrinology, diabetes & metabolism vol. 2,2 (2019): e00054. doi: https://doi.org/10.1002/edm2.54
Blain H, Sinaii N, Zeltser D, Lyssikatos C, Belyavskaya E, Keil M, Bluemke DA, Stratakis C, Bandettini WP, Lodish M. Aortic pulse wave velocity in children with Cushing syndrome: A window into a marker of early cardiovascular disease. Endocrinol Diabetes Metab. 2019 Jan 15;2(2):e00054. doi: 10.1002/edm2.54. eCollection 2019 Apr. PMID: 31008362; PMCID: PMC6458483.
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Endocrinol Diabetes Metab. 2019 Jan 15;2(2):e00054. doi: 10.1002/edm2.54. eCollection 2019 Apr.

Aortic pulse wave velocity in children with Cushing syndrome: A window into a marker of early cardiovascular disease.

Endocrinology, diabetes & metabolism

Hailey Blain, Ninet Sinaii, Deena Zeltser, Charalampos Lyssikatos, Elena Belyavskaya, Margaret Keil, David A Bluemke, Constantine Stratakis, Wiphada Patricia Bandettini, Maya Lodish

Affiliations

  1. Section on Endocrinology and Genetics Eunice Kennedy Shriver National Institute of Child Health Bethesda Maryland.
  2. Bowdoin College Brunswick Maine.
  3. Biostatistics and Clinical Epidemiology Service NIH Clinical Center Bethesda Maryland.
  4. Radiology and Imaging Sciences National Institute of Health Clinical Center Bethesda Maryland.
  5. University of Wisconsin School of Medicine and Public Health Madison Wisconsin.
  6. National Heart, Lung, and Blood Institute Bethesda Maryland.
  7. Department of Pediatrics University of California San Francisco California.

PMID: 31008362 PMCID: PMC6458483 DOI: 10.1002/edm2.54

Abstract

OBJECTIVE: To investigate early signs of cardiovascular arterial remodelling in paediatric patients with Cushing syndrome (CS) in comparison with normative values from healthy children.

STUDY DESIGN: The metrics used to assess cardiac health were from thoracic aorta and carotid MRI. Scans were performed on 18 children with CS (mean: 12.5 ± 3.1 years, range: 6.0-16.8 years, 10 female). Pulse wave velocity (PWV), aortic distensibility (AD) and carotid intima-media thickness (cIMT), well-validated measurements of cardiac compromise, were measured from the images and compared to normative age-matched values where available.

RESULTS: Patients with CS had significantly higher PWV compared to age-adjusted normal median control values (4.0 ± 0.7 m/s vs. 3.4 ± 0.2 m/s, respectively,

CONCLUSION: Pulse wave velocity data indicate that paediatric patients with CS have early evidence of cardiovascular remodelling. The results suggest the opportunity for monitoring as these changes begin in childhood.

Keywords: cardiology; heart disease; hypercortisolemia; paediatrics; pulse wave velocity

Conflict of interest statement

The authors have no conflicts of interest to declare.

References

  1. J Cardiovasc Pharmacol. 2001 May;37(5):512-21 - PubMed
  2. Hypertension. 2001 Oct;38(4):914-21 - PubMed
  3. J Clin Endocrinol Metab. 2003 Jun;88(6):2527-33 - PubMed
  4. Endocrinol Metab Clin North Am. 2005 Jun;34(2):327-39, viii - PubMed
  5. J Magn Reson Imaging. 2006 Aug;24(2):379-87 - PubMed
  6. Horm Metab Res. 2006 Jun;38(6):405-10 - PubMed
  7. Pediatrics. 2007 Sep;120(3):e575-86 - PubMed
  8. Clin Med (Lond). 2008 Apr;8(2):204-8 - PubMed
  9. J Clin Endocrinol Metab. 2009 Jun;94(6):2002-8 - PubMed
  10. Hypertension. 2010 Feb;55(2):319-26 - PubMed
  11. Cardiol Young. 2010 Dec;20(6):610-4 - PubMed
  12. J Pediatr Endocrinol Metab. 2010 Jun;23(6):627-35 - PubMed
  13. Endocrine. 2010 Apr;37(2):280-5 - PubMed
  14. Eur J Intern Med. 2012 Apr;23(3):278-82 - PubMed
  15. J Cardiovasc Magn Reson. 2012 Nov 14;14:77 - PubMed
  16. J Clin Endocrinol Metab. 2013 Jun;98(6):2277-84 - PubMed
  17. Hypertension. 2013 Sep;62(3):550-6 - PubMed
  18. J Clin Endocrinol Metab. 2014 Nov;99(11):E2144-53 - PubMed
  19. Clin Exp Hypertens. 2015;37(4):308-16 - PubMed
  20. Clin Endocrinol (Oxf). 2015 Jul;83(1):72-7 - PubMed
  21. Curr Opin Endocrinol Diabetes Obes. 2015 Feb;22(1):48-54 - PubMed
  22. Pediatr Diabetes. 2015 Mar;16(2):90-7 - PubMed
  23. Eur J Endocrinol. 2015 Oct;173(4):M133-57 - PubMed
  24. Atherosclerosis. 2015 Aug;241(2):376-86 - PubMed
  25. Arterioscler Thromb Vasc Biol. 2016 Jan;36(1):198-203 - PubMed
  26. J Pediatr. 2016 Mar;170:273-7.e1 - PubMed
  27. J Magn Reson Imaging. 2017 Jan;45(1):147-156 - PubMed
  28. J Pediatr. 2016 Oct;177:227-231 - PubMed
  29. Ann Med. 2017 May;49(3):206-216 - PubMed
  30. Pediatr Res. 2017 Aug;82(2):272-277 - PubMed
  31. Horm Res Paediatr. 2017;87(5):295-300 - PubMed
  32. Clin Endocrinol (Oxf). 1994 Apr;40(4):479-84 - PubMed

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