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Abughanimeh O, Kaur A, Numan L, et al. Zieve's Syndrome: An Under-reported Cause of Anemia in Alcoholics. Cureus. 2019;11(2):e4121doi: 10.7759/cureus.4121.
Abughanimeh, O., Kaur, A., Numan, L., Bahaj, W., & Madhusudhana, S. (2019). Zieve's Syndrome: An Under-reported Cause of Anemia in Alcoholics. Cureus, 11(2), e4121. https://doi.org/10.7759/cureus.4121
Abughanimeh, Omar, et al. "Zieve's Syndrome: An Under-reported Cause of Anemia in Alcoholics." Cureus vol. 11,2 (2019): e4121. doi: https://doi.org/10.7759/cureus.4121
Abughanimeh O, Kaur A, Numan L, Bahaj W, Madhusudhana S. Zieve's Syndrome: An Under-reported Cause of Anemia in Alcoholics. Cureus. 2019 Feb 22;11(2):e4121. doi: 10.7759/cureus.4121. PMID: 31037235; PMCID: PMC6478496.
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Cureus. 2019 Feb 22;11(2):e4121. doi: 10.7759/cureus.4121.

Zieve's Syndrome: An Under-reported Cause of Anemia in Alcoholics.

Cureus

Omar Abughanimeh, Anahat Kaur, Laith Numan, Waled Bahaj, Sheshadri Madhusudhana

Affiliations

  1. Internal Medicine, University of Missouri-Kansas City School of Medicine, Kansas City, USA.
  2. Hematology and Oncology, University of Missouri-Kansas City School of Medicine, Kansas City, USA.

PMID: 31037235 PMCID: PMC6478496 DOI: 10.7759/cureus.4121

Abstract

Anemia is a common finding in alcoholics. It is often multifactorial and caused by a combination of liver dysfunction, ineffective erythropoiesis, and poor nutrition. Zieve's syndrome (ZS) is a clinical syndrome that presents with a triad of jaundice, hemolytic anemia, and hyperlipidemia secondary to alcohol use. Herein, we present a case of a 58-year-old male with a history of liver cirrhosis who presented after a fall due to binge drinking and was found to have severe anemia. Workup was consistent with hemolytic anemia with no source of active bleeding. The patient was managed with supportive treatment and blood transfusions which improved his anemia. However, given his advanced liver disease, he developed encephalopathy and subsequently severe aspiration pneumonia. He died 18 days after admission.

Keywords: alcohol; anemia; hemolysis; hepatitis; jaundice; zieve's syndrome

Conflict of interest statement

The authors have declared that no competing interests exist.

References

  1. Ann Intern Med. 1958 Mar;48(3):471-96 - PubMed
  2. Am J Med. 2003 Dec 15;115(9):729-31 - PubMed
  3. Am Fam Physician. 2004 Feb 15;69(4):875-81 - PubMed
  4. Clin Lab Haematol. 1990;12(2):159-67 - PubMed
  5. ACG Case Rep J. 2015 Jul 09;2(4):250-1 - PubMed
  6. Am J Gastroenterol. 2016 Apr;111(4):577-9 - PubMed
  7. Gastroenterol Hepatol Bed Bench. 2016 Fall;9(4):335-339 - PubMed
  8. Medicine (Baltimore). 2017 Nov;96(47):e8742 - PubMed
  9. Am J Med Sci. 1968 May;255:277-87 - PubMed
  10. Br J Haematol. 1977 Apr;35(4):573-85 - PubMed

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