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Manur JG, Patel RB, Chandramouli S. Efficacy of preoperative chemoradiotherapy in downstaging rectal cancer and its impact on the long-term outcome. South Asian J Cancer. 2019;8(2):98-101doi: 10.4103/sajc.sajc_203_17.
Manur, J. G., Patel, R. B., & Chandramouli, S. (2019). Efficacy of preoperative chemoradiotherapy in downstaging rectal cancer and its impact on the long-term outcome. South Asian journal of cancer, 8(2), 98-101. https://doi.org/10.4103/sajc.sajc_203_17
Manur, Janaki Gururajachar, et al. "Efficacy of preoperative chemoradiotherapy in downstaging rectal cancer and its impact on the long-term outcome." South Asian journal of cancer vol. 8,2 (2019): 98-101. doi: https://doi.org/10.4103/sajc.sajc_203_17
Manur JG, Patel RB, Chandramouli S. Efficacy of preoperative chemoradiotherapy in downstaging rectal cancer and its impact on the long-term outcome. South Asian J Cancer. 2019 Apr-Jun;8(2):98-101. doi: 10.4103/sajc.sajc_203_17. PMID: 31069187; PMCID: PMC6498706.
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South Asian J Cancer. 2019 Apr-Jun;8(2):98-101. doi: 10.4103/sajc.sajc_203_17.

Efficacy of preoperative chemoradiotherapy in downstaging rectal cancer and its impact on the long-term outcome.

South Asian journal of cancer

Janaki Gururajachar Manur, Rahil Bharatbhai Patel, Sathish Chandramouli

Affiliations

  1. Department of Radiotherapy, M. S. Ramaiah Medical College, Bengaluru, Karnataka, India.
  2. Department of Surgical Oncology, M. S. Ramaiah Medical College, Bengaluru, Karnataka, India.

PMID: 31069187 PMCID: PMC6498706 DOI: 10.4103/sajc.sajc_203_17

Abstract

INTRODUCTION: Response to preoperative chemoradiation (PRTCT) for rectal cancer predicts the long-term outcome.

CONTEXT: Tertiary care hospital.

AIMS: The aim is to study the factors affecting the response to chemoradiation.

SETTINGS AND DESIGN: Retrospective.

MATERIALS AND METHODS: Twenty-three patients of rectal cancer undergoing PRTCT followed by surgery and adjuvant chemotherapy were followed up for 20-56 months. Postoperative response, tumor downstaging and nodal downstaging were correlated with the disease status.

RESULTS: Tumor downstaging was seen in 11 (50%) and nodal downstaging in 12 (63.15%) patients. Nodal downstaging was statistically significant with

CONCLUSION: Most patients of rectal cancer show PR to PRTCT, and the benefit is more for node-positive patients. Nodal PCR is associated with a higher chance of long-term disease control.

Keywords: Downstaging; long-term outcome; preoperative radiation; rectal cancer

Conflict of interest statement

There are no conflicts of interest.

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